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Proteases and Cancer
This volume details bioinformatics analysis, biochemical assays, recombinant protein expression and purification, methods to investigate protease activity in cell-based, organoids and in vivo systems, proteomics, transcriptomics, machine learning and novel approaches to target dysregulated protease activity in cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Immunotherapy: Methods and Protocols aims to provide the scientific community with a diverse and representative collection of state-of-the-art methods to investigate the protean functions of proteases in cancer biology.
ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era
Professor Hang Fai Kwok has two filed patents on ADAM17 antibody applications in cancer and cardiovascular disease. All other Topic Editors declare no competing interests with regards to the Research Topic.
Innovative Heat Exchangers
This accessible book presents unconventional technologies in heat exchanger design that have the capacity to provide solutions to major concerns within the process and power-generating industries. Demonstrating the advantages and limits of these innovative heat exchangers, it also discusses micro- and nanostructure surfaces and micro-scale equipment, and introduces pillow-plate, helical and expanded metal baffle concepts. It offers step-by-step worked examples, which provide instructions for developing an initial configuration and are supported by clear, detailed drawings and pictures. Various types of heat exchangers are available, and they are widely used in all fields of industry for cool...
Novel Approaches for Targeting Metalloproteinases
This Special Issue is a collection of eleven articles (five reviews and six studies) that describe a wide range of approaches to modulating metalloproteinase activity in disease. The techniques described are in vitro, in vivo, and ex vivo.
Intermundia
Dove nascono l’odio, la violenza, il sadismo? Qual è l’origine del male? Non esiste una risposta facile al più antico dei quesiti teologici e morali. Gli intermundia sono le dimensioni alternative che si aprono nell’universo della coscienza umana. Le chiavi per accedervi sono i pensieri malvagi inespressi, negati, le preghiere inascoltate e quelle male indirizzate. Una volta aperta l’anima a tali piani del reale, in cosa rischiamo di imbatterci? Ma, soprattutto, cosa potrebbe uscirne, trovando un varco nella nostra quotidianità per annientarla? Ognuno dei dieci racconti che compongono la silloge di esordio di Salvatore Santamaria è un tentativo di dissezionare i meccanismi e le cause dietro le più torbide passioni umane, uno squarcio aperto su questi intermundia.
