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Construction and utilization of digital twins for personalized therapeutic predictions
Modern healthcare faces a significant challenge, namely that 25-70% of patients with common diseases do not benefit from standard treatments despite the availability of over 13,000 drugs registered in DrugBank. This discrepancy is likely due to these diseases' complex and heterogeneous molecular nature rather than a lack of therapeutic options. Emerging technologies have revealed the immense molecular complexity underlying common diseases. For instance, singlecell RNA sequencing (scRNA-seq) has demonstrated altered gene interactions in and across multiple cell types in numerous tissues. Furthermore, these technologies have revealed vast molecular differences between patients with the same di...
Dixie Emporium
The ten essays in this collection focus on how southerners have marketed themselves to outsiders and identify spaces, services, and products that construct various Souths that exaggerate, refute, or self-consciously safeguard elements of southernness. Simultaneous.
Maverick Republican in the Old North State
Daniel Russell is a good example of what Carl Degler has termed “the other South.” The son of an aristocratic eastern North Carolina family of staunch Whig-Unionists, he entered politics when the Republican party first appeared in the state after the Civil War. For more than forty years thereafter he fought the solid South mentality of the Bourbon Democrats, first as a Radical Republican judge, then as a Greenbacker congressman, and finally as a Republican governor with Populist sympathies–the only chief executive of his party that North Carolina had between Reconstruction and the 1970s. The basic themes of Russell’s political life were racial and economic in nature. As a judge on th...
More Than a Runner’S High
Some runners (and other athletes) have experienced a feeling of total wellness and sense of euphoria after engaging in intense physical activity. This feeling has come to be known as runners high. What is this runners high and how can we experience more than a runners high? "Psychologically, runners may experience euphoria, a feeling of being invincible, a reduced state of discomfort or pain, and even a loss in sense of time while running," says Jesse Pittsley, PhD, president of the American Society for Exercise Physiologists.*
Sombreros and Motorcycles in a Newer South
In 1949, Alan Schafer opened South of the Border, a beer stand located on bucolic farmland in Dillon County, South Carolina, near the border separating North and South Carolina. Even at its beginning, the stand catered to those interested in Mexican-themed kitsch--sombreros, toy pinatas, vividly colored panchos, salsas. Within five years, the beer stand had grown into a restaurant, then a series of restaurants, and then a theme park, complete with gas stations, motels, a miniature golf course, and an adult-video shop. Flashy billboards--featuring South of the Border's stereotypical bandit Pedro--advertised the locale from 175 miles away. An hour south of Schafer's site lies the Grand Strand ...
