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How the FDA was shaped by public health crises and patient advocacy, told against a background of the contentious hearings on the breast cancer drug Avastin. Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer’s drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate US authority on a drug’s safety and efficacy? In Drugs and the FDA, Mikkael Sekeres—a leading oncologist and former chair of the FDA’s cancer drug advisory committee—tells the story of how the FDA became the most trusted regulatory agency in the world. It took a series of tragedies and health crises, as well as patient ...
Effective care of the cancer patient increasingly involves systemic treatment, and as the range of available therapeutic agents continues to expand, the medical oncologist must be fully aware of the rationale for choosing specific drugs and combinations. Textbook of Medical Oncology, 4th edition, is written by a highly acclaimed list of internation
This book provides the necessary information about not only the clinical aspects of caring for cancer survivors, but also the psychosocial impacts. There are multiple resources available to serve as oncology textbooks, but nothing to provide the necessary information on patient care for the non-MD members of the cancer patient management team. In the post-treatment phase, the management team must go beyond the realm of "conventional" follow-up, helping the patient to intellectually understand and emotionally grasp the path ahead. Cancer Survivorship will prove a vital tool to physicians, nurses, clinical social workers and mental health professionals.
This book was written both for survivors and health professionals, some of whom are cancer survivors, too. Our goal is to provide you with a survivor's road map. --Dr. Ernest H. Rosenbaum * More than 30 medical professionals reveal insights on surviving cancer to empower cancer survivors and their caregivers, as well as the doctors who manage their continued care. The CDC's National Action Plan for Cancer Survivorship estimates that there are 9.6 million persons living following a cancer diagnosis. And this number is strictly related to patients. It does not include family members, friends, or caregivers. For anyone approaching life from the perspective of remission, respected oncologist Dr....
The definitive text on Hodgkin lymphoma is now in its thoroughly revised, updated Second Edition. More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up. This edition describes the increased use of PET scanning in staging and follow-up. Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection. Full consideration is given to late effects of therapy and clinical trials for assessing quality of life in patients. This edition includes complete access to the fully searchable online text of the entire book with all the images at www.hodgkinlymphomasolution.com.
Bleomycin Chemotherapy focuses on the clinical uses of bleomycin. Bleomycin, a group of glycopeptides isolated from Streptomyces verticillus, has a unique structure and mechanism of action among anticancer drugs. The drug's remarkable lack of bone marrow toxicity prompted its addition to myelosuppressive regimens and enabled treatment of patients with compromised hematopoietic function. Bleomycin is an integral component of one of the great triumphs of medical oncology—the curative treatment of metastatic testicular carcinomas. Similar curative potential has been demonstrated for bleomycin in combination with cisplatin and vinblastine in germ-cell cancers of the ovary. Bleomycin is included in several important treatment regimens for Hodgkin's disease and non-Hodgkin's lymphomas. The drug also has clinical activity against squamous carcinomas of various sites. These uses and other aspects, including the development of new bleomycin analogs, are discussed in the following chapters, which were first presented at a symposium jointly sponsored by the Northern California Cancer Program and Bristol Laboratories in San Francisco, California, 14-15 September 1984.
Monoclonal antibodies are antibody molecules having homogeneous structure and known specificity. This book provides a basic and over all idea of research carried out in the field of monoclonals for the past three decades. This book discusses in detail the production of monoclonalanti bodies, the techniques used to make human monoclonals, the wide applications of monoclonals in various fields like medical,environmental, industrial and research and the FDA-approved monoclonal drugs with respect to their nature, their modes of action, and the experiments undertaken during their clinical trials, with appropriatediagrams and graphic illustrations. The book also discusses the research undertaken by various biotech companies, patents applied, and the present and future status of monoclonals in the drug market.
Effective care of the cancer patient increasingly involves systemic treatment, and as the range of available therapeutic agents continues to expand, the medical oncologist must be fully aware of the combinations. This new edition provides a practical overview of the many treatment choices, and has been fully updated, including discussion of new classification systems, anticancer agents and treatment protocols.
Human Lymphoma: The Clinical Implications of the REAL Classification is a unique volume. It is based on the recent developments in classification and overall understanding of human lymphoid neoplasms which are relatively common neoplasms and which epidemiological evidence suggests are increasing in frequency. This field has been the cause of confusion in the past as a result of conficting ideas on the classification of lymphoma and related diseases. However a new vision of the field has emerged and the is encapsulated in the pioneering REAL classification and in a forthcoming WHO scheme, both of which are covered in the book. The volume will appeal to hematologists, pathologists and oncologists and will, thanks to a diverse and expert authorship, serve to increase the working knowledge of all three groups.