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Son from Ukraine
After a long flight, Sandra and Albert Upeslacis step out of the aircraft and look upon Ukraine, a country with a rich heritage and culture that is, in the year 2000, still working to shake off the ghosts of Soviet occupation. A five-week stay lies ahead for the couple, and if all goes to plan, they will not be returning to Canada alone—through the many hurdles of international adoption, a young boy waits for them, unaware that soon, his family will find him. Son from Ukraine is the heartwarming true story of Sandra Upeslacis’s international adoption of her son. It shows in stunning detail the international adoption process, Ukraine at the turn of the century, and the cultural, linguistic, and bureaucratic realities of a post-Soviet country. This book is a must-read for anyone interested in international adoption and the history of Ukraine. Shining above every difficulty, however, is the story of love and a family taking its first tender steps into togetherness.
Canadian Almanac & Directory, 2015
The Canadian Almanac & Directory is the most complete source of Canadian information available - cultural, professional and financial institutions, legislative, governmental, judicial and educational organizations. Canada's authoritative sourcebook for al
Structure-based Design of Drugs and Other Bioactive Molecules
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both ...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
Bioisosteres in Medicinal Chemistry
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
