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Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment
Hematologic malignancies (HMs) represent a group of hematologic cancers originating from bone marrow or lymphoid organs. Currently, leukaemia, lymphoma, and multiple myeloma are the most common HMs. Conventional treatments for HMs include bone marrow transplantation, radiotherapy, chemotherapy, and immunotherapy. Despite the significant achievements obtained over the past decade in the drug therapy of HMs, tumor metastasis and relapse in patients often occurred after an initial response, indicating the generation of drug resistance to current therapies. Moreover, many clinically used therapeutic drugs are often associated with dose-related side effects and a lack of specificity to tumor tiss...
Where Chiang Kai-shek Lost China
“A masterful contribution not simply to the history of the civil war, but also to the history of 20th century China.” —Steven I. Levine author, Anvil of Victory: The Communist Revolution in Manchuria, 1945-1948) The civil war in China that ended in the 1949 victory of Mao Zedong’s Communist forces was a major blow to U.S. interests in the Far East and led to heated recriminations about how China was “lost.” Despite their significance, there have been few studies in English of the war’s major campaigns. The Liao-Shen Campaign was the final act in the struggle for control of China’s northeast. After the Soviet defeat of Japan in Manchuria, Communist Chinese and then Nationalist...
