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MicroRNAs (miRNAs) are small noncoding RNAs that are 19–24 nucleotides in length, following maturation. Recent evidence has demonstrated their key role as post-transcriptional regulators of gene expression through the binding of specific sequences within target messenger RNA (mRNA). miRNAs are involved in the synthesis of a very large number of proteins, and it is speculated that they could regulate up to 30% of the human genome. They control virtually every cellular process and are essential for animal development, cell differentiation, and homeostasis. Altered miRNA expression has been linked to such pathological events as inflammatory, degenerative, or autoimmune processes and have been...
Workplace health promotion and well-being are essential for raising awareness about potential health risks, and helping workers avoid them in order to lead a more fulfilling life. The present book presents the health risks that computer users are prone to and possible measures for the mitigation of said risks. For example, the book outlines the effects of different spa treatments for relieving muscular tension, which can be a side effect of the sedentary nature of computer use in the workplace. In addition to physical inactivity, computer users also suffer from unhealthy eating habits. So, the book also outlines dietary and physical activity recommendations for people working with computers and suggests measures for employers to implement in the office. Working long hours on the computer leaves a mark on one’s mental health; the adverse effects are related to addictions or the infliction of stressful situations like cyberbullying. In recent years, online working or meeting environments have become popular, which has led to the emergence of Zoom fatigue. The current book provides suggestions for participating in online meetings more healthily.
This book provides a comprehensive outlook of expected long-term economic changes in the Western Balkans, inspiration for involved decision-makers, and ways to leverage the opportunities of the COVID-19 pandemic. It considers how the organizational aspects of enterprises, changes in consumer behavior, the rise of informational technologies, and the expansion of the digital market can create economic growth based on lower carbon consumption and sustainable growth based on green and clean solutions. The length and depth of the current economic crisis will depend on a combination of effective policies, incentives and management systems that can balance between the protection of public health and economic well-being.
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In this issue of Hand Clinics, guest editors Drs. Phillip Ross and Sarah E. Sasor bring their considerable expertise to the topic of the Thumb CMC Joint. Top experts in the field discuss different strategies for the management of problems with the thumb carpometacarpal (CMC) joint, as well as treatment options. - Contains 14 relevant, practice-oriented topics including joint-preserving treatments for thumb CMC osteoarthritis; thumb CMC implant arthroplasty; revision CMC arthroplasty; diagnosis and treatment of CMC instability; and more. - Provides in-depth clinical reviews on the thumb CMC joint, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
A graduate textbook on the interdisciplinary significance of hydroclimatology, explaining the relationship between the climate system and the hydrologic cycle.
This open access book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation. Based on the available best external evidence, clinical pathways are described for stroke rehabilitation bridging the gap between clinical evidence and clinical decision-making. The clinical pathways answer the questions which rehabilitation treatment options are beneficial to overcome specific impairment constellations and activity limitations and are well acceptable to stroke survivors, as well as when an...
a sound and though guide for all future spa managers looking at all aspects on the successful running of a spa facility. Divided into four parts it discusses the following: • The spa industry • The spa consumer • The business of spas • Future directions