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ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
The development of hypothesis of oxidative stress in the 1980s stimulated the interest of biological and biomedical sciences that extends to this day. The contributions in this book provide the reader with the knowledge accumulated to date on the involvement of reactive oxygen species in different pathologies in humans and animals. The chapters are organized into sections based on specific groups of pathologies such as cardiovascular diseases, diabetes, cancer, neuronal, hormonal, and systemic ones. A special section highlights potential of antioxidants to protect organisms against deleterious effects of reactive species. This book should appeal to many researchers, who should find its information useful for advancing their fields.
With contributions by numerous experts
- Esta obra, que se convierte en el primer libro publicado sobre esta temática en español, presenta un abordaje íntegro y detallado de todos los temas que giran en torno a la neurocardiología y que van desde la investigación básica, los fundamentos fisiopatológicos y la clínica de las enfermedades neurocardiológicas. - Obra de contenido innovador pero que aborda patologías de mucha prevalencia en la sociedad actual, como pueden ser la diabetes, la cardiopatía isquémica, las arritmias, la HTA, etc. - Los autores tratarán tanto la estructura como el funcionamiento normal del sistema nervioso cardíaco con un enfoque moderno en base a una jerarquía neuronal para la regulación de ...
The first book to provide a broad coverage of Thai legal history in the English language.
Industrial Biorefineries and White Biotechnology provides a comprehensive look at the increasing focus on developing the processes and technologies needed for the conversion of biomass to liquid and gaseous fuels and chemicals, in particular, the development of low-cost technologies. During the last 3-4 years, there have been scientific and technological developments in the area; this book represents the most updated information and technological perspective on the topic. - Provides information on the most advanced and innovative pretreatment processes and technologies for biomass - Covers information on lignocellulosic and algal biomass to work on the principles of biorefinery - Provides information on integration of processes for the pretreatment of biomass - Designed as a textbook for both graduate students and researchers
Stability constants are fundamental to understanding the behavior of metal ions in aqueous solution. Such understanding is important in a wide variety of areas, such as metal ions in biology, biomedical applications, metal ions in the environment, extraction metallurgy, food chemistry, and metal ions in many industrial processes. In spite of this importance, it appears that many inorganic chemists have lost an appreciation for the importance of stability constants, and the thermodynamic aspects of complex formation, with attention focused over the last thirty years on newer areas, such as organometallic chemistry. This book is an attempt to show the richness of chemistry that can be revealed...
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on ...
In modern polymer science a variety of polymerization methods for the direct synthesis of polymers bearing functional groups are known. However, there is still a large number of functional groups that may either completely prevent polymerization or lead to side reactions. Post-polymerization modification, also known as polymer-analogous modification, is an alternative approach to overcome these limitations. It is based on the polymerization of monomers with functional groups that are inert towards the polymerization conditions but allow a quantitative conversion in a subsequent reaction step yielding a broad range of other functional groups. Thus, diverse libraries of functional polymers wit...