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This is the first book to describe the pharmacological interaction of drugs and exercise with organ systems at molecular and cellular levels. It explains the effect of exercise on pharmacokinetics and pharmacodynamics of drugs, and the activation or induction of antioxidant enzymes which may take place via the adenosine receptor or may occur due to gene expression.
The proceedings of the April 1997 hearing on the status of the Dept. of Veterans Affairs to Identify Gulf War Syndrome. Examines, in particular, the impact of missing, classified, or incomplete medical records on Gulf War veterans' health. Testimony, letters & statements are included from a number of representatives of the Defense Dept. (Deputy Inspector General, Special Assistant for Gulf War Illnesses), military, & Federal government as well as medical practitioners & researchers, including: Monterey Inst. of International Studies; Southern Illinois Univ. School of Medicine; Special Assistant for Gulf War Illnesses, CIA, etc. Tables & photos.
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
The Handbook of Chemical and Biological Warfare Agents, Volume 1: Military Chemical and Toxic Industrial Agents, Third Edition provides rapid access to key data to response professionals and decision-makers on a broad range of agents and pathogens. This volume examines military chemical agents that were developed for their lethal effects and includes chapters on nerve agents, vesicants, urticants, convulsants, blood agents, and pulmonary agents. It also details toxic industrial materials that are considered potential threat for use as improvised agents. In addition to a discussion of each of these classes of agents, coverage includes detailed information on a broad spectrum of individual age...
Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.
Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have few
This volume collates articles investigating antioxidant, oxidant and free radical research. It examines the role of such research in health and disease, particulary with respect to developing greater understanding about the many interactions between oxidants and antioxidants, and how such substances may act as natural protectants and /or natural toxicants.
Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e
Up to the last decade or so, most general modeling approaches to the study of molecular components of biological responses have required significant amount of computer time, expertise, and resources, as well as highly specialized and often custom-written programs. With Biomedical Applications of Computer Modeling you don't have to be a computer sci