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Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.
"QSAR and Molecular Modeling" includes all the fundamentals of these approaches developed so far. Starting with the fundamentals of drug-receptor interactions, it covers various statistical approaches, different 2D QSAR methodologies, theories and values of useful variables governing biological activities, and popular 3D molecular modeling approaches. The book comprehensively covers these topics in one text.
The goal of modern dentistry is to restore the patient function, comfort, esthetics speech & health, which can be done by removing caries from a tooth and restoring it, or by replacing missing teeth. What makes implant dentistry unique is the ability to achieve this goal, regardless of atrophy, disease, or any injury of the stomatognathic system. As a result of latest researches, diagnostic tools, treatment planning, implant designs, materials and techniques, predictable success is now a reality for the rehabilitation of many challenging clinical situations. Dental implants are the treatment of choice for the replacement of missing teeth nowadays. However, placement of the implant in alveolar bone remains a challenge for most of the clinicians due to the resorption of the residual alveolar ridge, resulting in insufficient bone volume in one or more dimensions. The purpose of this book is to discuss and elaborate the review various complications and failures in implantology before and after the placement of a dental implant.
This book offers a unique perspective for Medical Astrology Students who aspire to become Medical Astrologers or those who want to deepen their understanding of Medical Astrology by integrating it with the principles of Medical Science. This book does not cover any remedy, medical course, or curriculum; it is for medical astrology students who want to combine astrology with medical problems caused by INSULIN RESISTANCE. This book does not cater to beginners in astrology; it is specifically tailored for advanced students of Medical Astrology who have some prior knowledge of Medical Science. This is not a predictive book on Medical Astrology or does not teach you the timing of disease. It is a...
Cellulose and cellulose derivatives are a class of bio-based materials that have attracted scientific interest due to their unique structural features and properties such as biocompatibility, biodegradability, and renewability. They are promising candidates for applications in biomedicine, pharmaceuticals, electronics, barrier films, nanocomposites, membranes, and supercapacitors. New resources, extraction procedures, and treatments are currently under development to satisfy increasing demands for cost-effective and sustainable methods of manufacturing new types of cellulose nanoparticle-based materials on an industrial scale. This book, written by an international collection of contributors in the field, is a useful reference for graduate students and researchers in chemistry, materials science, nanoscience, and green nanotechnology.
This book is all about decoding the combination of Raja Yoga of Millionaire. The author explains these principles from his case studies using Bhrigu Nandi Nadi and Parashara Jyotish: 1. Raj Yoga and Millionaire Yoga with Rahu in Bhrigu Nandi Nadi. 2. Raj Yoga and Millionaire Yoga with Jupiter in Bhrigu Nandi Nadi. 3. Raj Yoga and Millionaire Yoga from the Kendra and Trikon concept of Parashara Rishi. 4. Raj Yoga and Millionaire Yoga with Vipreet Raj Yoga. 5. Raj Yoga and Millionaire Yoga with Apokilam Bhavas. 6. Raj Yoga and Millionaire Yoga with Panphar Bhavas.
This traces the history of the Mughal empire from its creation in 1526 to its breakup in 1720. It stresses the quality of Mughal territorial expansion, their innovation in land revenue, military organization, and the relationship between the emperors and I
Love can't be explained completely. It can't be explained why it happens or how to find it.But when you find it, love heals you and gives you strength and peace apart from all the rest world.The moment when a stranger feels like home and someone more close than the world ,when you can be completely weird together, you smile for no reason and dance with a happy heart. When you find someone who doesn't judge you but loves you in the worst days in all ways.No matter where you are or how the situation change, the one person who holds your hand so tight in the storms too right. When the world feel better with each other . The feelings are just Beyond all reasons
Papers presented at the International Symposium on Land Degradation: New Trends towards Sustainable Agriculture and the Commonwealth Geographical Bureau Food Security Workshop organized by Dept. of Geography, M.M.H. College, Ghaziabad, India, on 7-12 April, 2002.
The book offers a fresh and timely perspective on the broader field of early postcolonial South Asian history.