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The Family on Trial in Revolutionary France
Annotation A sophisticated and groundbreaking book on what women actually did and what actually happened to them during the French Revolution.
Breakthroughs in Melanoma Research
Melanoma is considered to be one of the most aggressive forms of skin neoplasms. Despite aggressive researches towards finding treatments, no effective therapy exists to inhibit the metastatic spread of malignant melanoma. The 5-year survival rate of metastatic melanoma is still significantly low, and there has been an earnest need to develop more effective therapies with greater anti-melanoma activity. Through the accomplishment of over 100 distinguished and respected researchers from 19 different countries, this book covers a wide range of aspects from various standpoints and issues related to melanoma. These include the biology of melanoma, pigmentations, pathways, receptors and diagnosis, and the latest treatments and therapies to make potential new therapies. Not only will this be beneficial for readers, but it will also contribute to scientists making further breakthroughs in melanoma research.
The Inflammasomes
The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.
Frontiers in Medicinal Chemistry
"Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. Medicinal chemistry as.
Louis Sébastien Mercier
French playwright, novelist, activist, and journalist Louis Sébastien Mercier (1740–1814) passionately captured scenes of social injustice in pre-Revolutionary Paris in his prolific oeuvre but today remains an understudied writer. In this penetrating study—the first in English devoted to Mercier in decades—Michael Mulryan explores his unpublished writings and urban chronicles, Tableau de Paris (1781–88) and Le Nouveau Paris (1798), in which he identified the city as a microcosm of national societal problems, detailed the conditions of the laboring poor, encouraged educational reform, and confronted universal social ills. Mercier’s rich writings speak powerfully to the sociopolitical problems that continue to afflict us as political leaders manipulate public debate and encourage absolutist thinking, deepening social divides. An outcast for his polemical views during his lifetime, Mercier has been called the founder of modern urban discourse, and his work a precursor to investigative journalism. This sensitive study returns him to his rightful place among Enlightenment thinkers.
Theatrical Costume, Masks, Make-up and Wigs
This is the first bibliography in its field, based on first-hand collations of the actual articles. International in scope, it includes publications found in public theatre libraries and archives of Barcelona, Berlin, Brussels, Budapest, Florence, London, Milan, New York and Paris amongst others. Over 3500 detailed entries on separately published sources such as books, sales and exhibition catalogues and pamphlets provide an indispensible guide for theatre students, practitioners and historians. Indices cover designers, productions, actors and performers. The iconography provides an indexed record of over 6000 printed plates of performers in role, illustrating performance costume from the 18th to 20th century.
