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Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycop...
Alan Dundes defines myth as a sacred narrative that explains how the world and humanity came to be in their present form. This new volume brings together classic statements on the theory of myth by the authors. The twenty-two essays by leading experts on myth represent comparative, functionalist, myth-ritual, Jungian, Freudian, and structuralist approaches to studying the genre.
Presenting a personnel management philosophy, supported by evidence of practice, thiis book provides emphasis on performance, career development, skills and managing diversity. The strategic aspects and the skills involved in HRM are examined. An LPBB edition is available.
As humanity has expanded its horizon to see things vastly smaller, faster, larger and farther than before, it has been forced to confront preconceptions born of the human experience and create wholly new ways of looking at the world. Relativity and Quantum Physics For Beginners describes the revolutionary theories of relativity and quantum physics and shows how these ideas have led to amazing advances in the understanding of the universe.
At the end of the nineteenth century, numerous painters succumbed to the charms of the Orient. Travel to distant lands was easier, and artists brought back voluptuous images filled with sun and colour. This title studies almost 150 painters, from Delacroix to Ziem. It features many lesser known masters and is suitable for collectors.
The study of Islamic law can be a forbidding prospect for those entering the field for the first time. Wael Hallaq, a leading scholar and practitioner of Islamic law, guides students through the intricacies of the subject in this absorbing introduction. The first half of the book is devoted to a discussion of Islamic law in its pre-modern natural habitat. The second part explains how the law was transformed and ultimately dismantled during the colonial period. In the final chapters, the author charts recent developments and the struggles of the Islamists to negotiate changes which have seen the law emerge as a primarily textual entity focused on fixed punishments and ritual requirements. The book, which includes a chronology, a glossary of key terms, and lists of further reading, will be the first stop for those who wish to understand the fundamentals of Islamic law, its practices and history.
Advances in second language teaching methodology, including new emphases on communicative language teaching and learner-centeredness, have significantly changed the roles teachers play in the classroom, making ever greater demands upon their classroom management skills. For Nunan and Lamb, "management" refers to the planning and creation of a positive pedagogical environment which facilitates learning. They focus on the kinds of professional decisions teachers must make to ensure that learning takes place effectively. The ultimate aim of the book is to help teachers and teachers-in-preparation become "self-directed" by providing them with the knowledge and skills needed to take effective control of the teaching and learning processes in their classrooms. The Self-directed Teacher prepares teachers to make independent decisions in key areas such as lesson planning, teacher talk, group work, error correction, resource management, and evaluation. The text uses a task-based approach, and the material presented is well supported by theory and research.