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GABA and Sleep
GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.
Primary Care Sleep Medicine
This book provides a state-of-the-art, comprehensive overview of the diagnosis and treatment of sleep disorders. It details evidence-based practice recommendations using parameters primarily developed by the American Academy of Sleep Medicine. The book offers a thorough and extensive board review for specialization in sleep medicine and supports primary care clinicians in appropriately using sleep diagnostic testing results in clinical practice.
Narcolepsy
Narcolepsy serves as a prototype of how the interaction of high quality clinical research and groundbreaking basic science can collaborate to defne the cause of a disease and change forever how we evaluate and treat it. There is scarcely a topic in this book that would have been covered in the same way 10 years ago as it is d- cussed today. We are also fortunate that many of the players in this dramatic tu- around have contributed to this volume, so that the result is a tapestry of the events that have transformed the feld over the last decade that is both authentic and detailed. The frst section of the book provides much of the basic science background. As described in the frst two chapters, the dramatic convergence of lines of evidence from two different laboratories frst demonstrated in 1999 that narcolepsy is a disease of loss of neurotransmission by lateral hypothalamic neurons making the peptides that have been called orexins or hypocretins. These fndings did much to clarify and unify a feld that had puzzled for decades over the fundamental nature of this puzzling disease, as refected in the chapters that review its epidemiology and neuroanatomical and imaging fndings.
Synopsis of Sleep Medicine
Sleep medicine encompasses an unusually board spectrum of contributions from biology, technology, and medicine. This volume summarizes the considerable mass of knowledge that has been accumulated in the field and imparts its major findings in a manner that is comprehensive yet not overwhelming. Edited by an eminent sleep researcher and with contributions from leading experts in the field, the volume provides a basic grounding in sleep medicine and covers the fascinating complexity of the field. It separates figure from ground for those who are newcomers to the field and who are seeking guideposts for further research. Sleep problems are frequently co-morbid with other medical conditions, and clinicians need to be alert to this interconnectedness and to recognize which difficulties are primary and which are not. Synoposis of Sleep Medicine will be a valuable tool for clinicians in many specialties for addressing diagnostic problems in sleep medicine. The volume is the first of its kind, rich yet comprehensive and focused and one that is sure to meet the needs of both basic and clinical research for some years to come.
Melatonin in the Promotion of Health, Second Edition
Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states, Melatonin in the Promotion of Health, Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including: Gut motility and gastrointesti...
Primary Care Sleep Medicine
This book provides a state-of-the-art, comprehensive overview of the diagnosis and treatment of sleep disorders. It details evidence-based practice recommendations using parameters primarily developed by the American Academy of Sleep Medicine. The book offers a thorough and extensive board review for specialization in sleep medicine and supports primary care clinicians in appropriately using sleep diagnostic testing results in clinical practice.
Schlank über Nacht
Das Grundproblem der meisten Diäten liegt darin, dass sie nicht dauerhaft wirken. Anstatt auf eine Umstellung der Ernährung setzen sie auf kurzfristige Effekte. So schrumpfen zwar zunächst die Fettpolster, auf dass sie dann aber nach Abschluss der Kur erst richtig anschwellen. Der berühmte Jojo-Effekt lässt sich allerdings nur ausbremsen, wenn es gelingt, falsche Essgewohnheiten auch langfristig zu ändern. Das Bauchfett spielt dabei eine Schlüsselrolle. Hier werden Boten- und Entzündungsstoffe produziert, die Gefäße und Gelenke schädigen und den Stoffwechsel entgleisen lassen. An diesem Punkt setzt das neue Ernährungstraining von "Schlank über Nacht" an. Entscheidend dabei ist, dass jedes Ziel ohne Anstrengung erreichbar ist und man so die ungeliebten und gefährlichen Fettpolster langsam, aber sicher zum Schwinden bringt. Mit Hilfe der beigelegten Kontrolltabelle gelingt es, auch unter Alltagsbedingungen am Ball zu bleiben. Innerhalb von nur fünf Wochen wird ein Mehr an Lebensqualität erreicht, und der Leser erfährt, was wirklich nötig ist, um dauerhaft schlank und gesund zu bleiben.
Il duello dei neurochirurghi
Il 30 giugno 1559, nel corso di una giostra cavalleresca, il re di Francia Enrico II viene colpito alla testa dal conte di Montgomery: morirà una decina di giorni dopo, nonostante convergano e ‘duellino’ nell’assisterlo un grande chirurgo militare come Ambroise Paré e un grande anatomista come Andrea Vesalio. Innesco del nuovo, incalzante libro di Sam Kean, l'episodio segna anche l'avvio della moderna parabola neuroscientifica. Intrecciando le odissee di pazienti ‘memorabili’ (psicopatici assassini di presidenti americani e gemelle siamesi, ma anche tanti uomini e donne comuni) con le arditezze sperimentali dei medici che li hanno studiati e curati, Kean mostra i nessi profondi t...
Melatonin
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a wide spectrum of research on melatonin.
Narcolepsy
This comprehensive resource covers the current thoughts and trends on narcolepsy, as well as cutting-edge evidence-based research. Updates from the previous edition include advances in diagnostic guidelines, treatments, protocols and clinical and psychosocial considerations. Aspects of narcolepsy relating to sleep medicine, neurology, psychiatry and public health are featured throughout the text. Narcolepsy, 2nd Edition provides clinicians and allied health professionals with patient management modalities, clinical and quality of life issues and best practices for health care delivery.
