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Transcriptional Regulation by Neuronal Activity
  • Language: en
  • Pages: 426

Transcriptional Regulation by Neuronal Activity

Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. This book offers an up-to-date picture of the field.

Synaptic Plasticity
  • Language: en
  • Pages: 224

Synaptic Plasticity

Nerve cells form thousands of contact points, the synapses, to communicate information with other neurons and target cells. Synapses are sites for changes in brain function through modification of synaptic transmission termed synaptic plasticity. The study of synaptic plasticity has flourished over the years with the advancement of technical breakthroughs and is a timely scientific endeavor today just like it was several decades ago. This book contributes to our understanding of synaptic plasticity at the molecular, biochemical, and cellular systems and behavioral level and informs the reader about its clinical relevance. The book contains ten chapters in three sections: (1) "Mechanisms of S...

Transcriptional Regulation by Neuronal Activity
  • Language: en
  • Pages: 589

Transcriptional Regulation by Neuronal Activity

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Synaptic Tagging and Capture
  • Language: en
  • Pages: 507

Synaptic Tagging and Capture

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Methods for Synaptic Interrogation
  • Language: en
  • Pages: 276

Methods for Synaptic Interrogation

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Synaptic Plasticity and Transsynaptic Signaling
  • Language: en
  • Pages: 554

Synaptic Plasticity and Transsynaptic Signaling

Brain functions are realized by the activity of neuronal networks composed of a huge number of neurons. The efficiency of information transfer within the networks is changeable. Even the networks themselves can change through experience. Information transfer between neurons is performed at the synapse (the site of the neurons’ contact) by release of neurotransmitters from the pre-synaptic cell and capture of neurotransmitters by the post-synaptic cell. The amount of released neurotransmitter or the efficacy of capture can change. Moreover, synapses are found to be newly formed upon activity or abandoned upon inactivity. These changes are called "synaptic plasticity". This text focuses on one component of synaptic plasticity called transsynaptic signaling, or communication of synapses during their formation.

Complexity in Biological Information Processing
  • Language: en
  • Pages: 266

Complexity in Biological Information Processing

Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically or...

Hebbian Learning
  • Language: en
  • Pages: 129

Hebbian Learning

What Is Hebbian Learning The Hebbian theory is a neuropsychological theory that asserts that an improvement in synaptic efficacy results from the repetitive and persistent stimulation of a postsynaptic cell by a presynaptic cell. This is an effort to explain synaptic plasticity, which refers to the process through which neurons in the brain change in response to learning. It was first presented in Donald Hebb's book titled The Organization of Behavior, which was published in 1949. Hebb's rule, Hebb's postulate, and the cell assembly hypothesis are all names for the same body of thought. The way that Hebb expresses it is as follows: Let us assume that the persistence or repetition of a reverb...

Principles of Neurobiology
  • Language: en
  • Pages: 761

Principles of Neurobiology

Principles of Neurobiology, Second Edition presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary literature. Written by a single author in a clear and consistent writing style, each topic builds in complexity from electrophysiology to molecular genetics to systems level in a highly integrative approach. Students can fully engage with the content via thematically linked chapters and will be able to read the book in its entirety in a semester-long course. Principles of Neurobiology is accompanied by a rich package of online student and instructor resources including animations, figures in PowerPoint, and a Question Bank for adopting instructors.

Dendritic spines: from shape to function
  • Language: en
  • Pages: 237

Dendritic spines: from shape to function

One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dend...