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The functional anatomy of organisms is maintained by the coordination of different systems, that often rely on particular interactions between specialized cells and between macromolecules. The immune system works with the circulatory and the lymphatic systems to protect most of the organs. However, some organs are considered immune privileged due to the presence of highly selective and regulated barriers, such as the blood-brain barrier (BBB) within the brain. The BBB controls periphery-brain molecule exchange and prevents immune effector cells from entering the homeostatic brain. BBB-associated elements, such as endothelial cells, pericytes, astrocytes, and microglia, potentially can functi...
This book is the first attempt to provide a general theory of self-destruction in complex systems applicable to natural, social and cultural phenomena. The contributors work collaboratively to prove that many of the nondistributed complex systems in nature and society sooner or later experience critical development leading to unintended and irreversible self-annihilation. The individual chapters also show that the relations of such systems to their own distinctiveness and other systems may result in specific communicative pathologies (such as redundancy, inflation and noisy signalling) which tend to mitigate or reinforce each other, depending on circumstances. Finally, the volume updates som...
The genome revolution of the last twenty years has changed biology forever. It has provided stunning insights into the evolution of species (such as ours) and the development of new functional capabilities (such as placenta, brain, and immune networks). We are learning how genes make a human animal―but that loving relationships with others are required to make a human person. Random mutations, filtered by directing order, underlie evolutionary development, but also cause diseases such as cancer. We are wont to question God when faced with devastating natural and moral evils. But deeply embedded in the biblical story we encounter a Creator who has always purposed to deal with the evils of a freely operating world by extirpating them through Jesus of Nazareth, who is God incarnate.
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Before widescale emigration in the early 1960s, North Africa's Jewish communities were among the largest in the world. Without Jewish emigrants from North Africa, Israel's dynamic growth would simply not have occured. North African Jews, also called Maghribi, strengthed the new Israeli state through their settlements, often becoming the victims of Arab-Israeli conflicts and terrorist attacks. Their contribution and struggles are, in many ways, akin to the challenges emigrants from the former Soviet Union are currently encountering in Israel. Today, these North African Jewish communities are a vital force in Israeli society and politics as well as in France and Quebec. In the first major poli...