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Chemokine Receptors as Drug Targets
Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
Synthetic Immunology
This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity o...
Recent CMV Research
Printed Edition of the Special Issue Published in Viruses
New Cytokines as Potential Drugs
Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in this class of drugs arises from the fact that today we have a far better understanding of the human immune response, both at a cellular and molecular level. This has resulted in a more methodical characterisation of these factors which has given clinical researchers an opportunity to plan Phase 1 clinical trials that can provide substantial information on the activity of the cytokine in humans. Currently, a great deal of effort is also being channelled into identifying cytokines from the various DNA databases. Our major objective for this book is to profile cytokines that have been recently identified. The therapeutic potential of these cytokines based on their known properties will be discussed by the authors. The main aim of this book is to provide...
Chemokines, Part A
The understanding of chemokines, the proteins that control the migration of cells, and their receptors, is critical to the study of causes and therapies for a wide range of human diseases and infections, including certain types of cancer, inflammatory diseases, HIV, and malaria. This volume, focusing on chemokines as potential targets for disease intervention, and its companion volume (Methods in Enzymology volume 462, focusing on chemokine structure and function, as well as signaling) provide a comprehensive overview and time-tested protocols in this field, making it an essential reference for researchers in the area. Along with its companion volume, provides a comprehensive overview of chemokine methods, specifically as related to potential disease therapy Gathers tried, tested, and trusted methods and techniques from top players in chemokine research Provides an essential reference for researchers in the field
Teaching Tomorrow's Medicine Today
From Mount Sinai Department of Surgery chairman Arthur H. Afuses, Jr. and archivist Barbara Nuss, an instructional account of Mount Sinai's teaching methods The Mount Sinai Hospital was founded in 1852 as the Jews’ Hospital in the City of New York, but more than a century would pass before a school of medicine was created at Mount Sinai. In Teaching Tomorrow’s Medicine Today, Arthur H. Aufses, Jr., chairman of Mount Sinai's Department of Surgery, and archivist Barbara Niss chronicle the development of the medical school from its origins in the 1960s to the current leadership. The authors examine the social forces that compelled the world-renowned hospital to remake itself as an academic medical center, revealing the school's departure from and subsequent return to its founders' original vision. In addition to a compelling history of each of Mount Sinai’s departments, Teaching Tomorrow’s Medicine Today describes the school’s methods for providing both graduate or resident training and post-graduate physician education. Recognizing Mount Sinai’s central mission as a teaching institution, the authors close their account with perspectives of alumni and current students.
Annals of Life Insurance Medicine 5
In the preface to Volume 1 of the 'Annals of Life Insurance Medicine' Dr. MAX E. EISENRING described the goal of this publication as follows: "Any project which aims at contributing substantially to the modern science of medical underwriting can do so only if the many people preoccupied with these problems throughout the world join forces to the ultimate benefit of those most in need of life assurance." In an endeavour to keep the life insurance medical directors all over the world informed of the developments in the field of life insurance medicine, we have decided to publish the papers which were presented at the 11 th International Congress of Life Assurance Medicine in Mexico in 1973 in ...
Students of Revolution
Students played a critical role in the Sandinista struggle in Nicaragua, helping to topple the US-backed Somoza dictatorship in 1979—one of only two successful social revolutions in Cold War Latin America. Debunking misconceptions, Students of Revolution provides new evidence that groups of college and secondary-level students were instrumental in fostering a culture of insurrection—one in which societal groups from elite housewives to rural laborers came to see armed revolution as not only legitimate but necessary. Drawing on student archives, state and university records, and oral histories, Claudia Rueda reveals the tactics by which young activists deployed their age, class, and gende...
