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The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits
  • Language: en
  • Pages: 236

The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits

Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the applicat...

Highly Contiguous Plant Genome Assembly and Transcriptional Regulation
  • Language: en
  • Pages: 133

Highly Contiguous Plant Genome Assembly and Transcriptional Regulation

Highly contiguous reference genome sequences are a prerequisite for genomics research and for the optimal utilization of plant species. However, whole-genome duplication events and subsequent chromosomal rearrangements and losses shape the complex features and extensive diversity of plant genomes, and hinder their highly contiguous assembly. With the advent of single-molecule, long-read sequencing technologies, such as PacBio High-Fidelity (HiFi) and Oxford Nanopore Technologies (ONT), as well as Bionano genomics and high-throughput chromatin conformation capture (Hi-C), many highly complex chromosome-level genomes have been revealed, even with phased haplotypes. These advanced sequencing te...

Inheritance and Improvement of Disease Resistance or Stress Tolerance for Triticeae Crops
  • Language: en
  • Pages: 122
Worlds of Bronze and Bamboo
  • Language: en
  • Pages: 336

Worlds of Bronze and Bamboo

Sima Qian (c. 100 B.C.E.) was China's first historian—he was known as Grand Astrologer at the court of Emperor Wu during the Han dynasty—and, along with Confucius and the First Emperor of Qin, was one of the creators of imperial China. His Shiji (published for Columbia in a translation by Burton Watson as Records of the Grand Historian) not only became the model for the twenty-six Standard Histories that the historians of each Chinese dynasty wrote to legitimize the dynastic succession, but also has been an enormously influential resource to historians, literary scholars, philosophers, and many others seeking an understanding of early Chinese history. In Worlds of Bronze and Bamboo, Gran...

Manipulating the Immunological Tumor Microenvironment
  • Language: en
  • Pages: 792

Manipulating the Immunological Tumor Microenvironment

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Witchcraft and the Rise of the First Confucian Empire
  • Language: en
  • Pages: 290

Witchcraft and the Rise of the First Confucian Empire

Finalist for the 2015 Best First Book in the History of Religions presented by the American Academy of Religion Winner of the 2014 Academic Award for Excellence presented by Chinese Historians in the United States When did Confucianism become the reigning political ideology of imperial China? A pervasive narrative holds it was during the reign of Emperor Wu of the Han dynasty (141–87 BCE). In this book, Liang Cai maintains that such a date would have been too early and provides a new account of this transformation. A hidden narrative in Sima Qian's The Grand Scribe's Records (Shi ji) shows that Confucians were a powerless minority in the political realm of this period. Cai argues that the notorious witchcraft scandal of 91–87 BCE reshuffled the power structure of the Western Han bureaucracy and provided Confucians an opportune moment to seize power, evolve into a new elite class, and set the tenor of political discourse for centuries to come.

Combating cancer with natural products: Non-coding RNA and RNA modification
  • Language: en
  • Pages: 273
The Siren and the Sage
  • Language: en
  • Pages: 268

The Siren and the Sage

The cultures of ancient China and ancient Greece have exerted immeasurable influence on later civilizations. The texts and cultural values of classical China spread throughout East Asia and became the foundation of learning in Korea, Japan and Vietnam. Greek learning and culture receive credit for many of the intellectual paradigms of the West. Probably the one which is most distinctly Western is the tradition of logical proof and the related assumption that, as Aristotle put it in 'Metaphysics' 980, 'we all desire to know.' In contrast, the Chinese tradition, as exemplified by Laozi's 'Dao de jing,' cautions that through our desire to know we may forfeit wisdom, thus engendering a split bet...

Non-covalent Interactions in the Synthesis and Design of New Compounds
  • Language: en
  • Pages: 477

Non-covalent Interactions in the Synthesis and Design of New Compounds

This book aims to overview the role of non-covalent interactions, such as hydrogen and halogen bonding, π-π, π-anion and electrostatic interactions, hydrophobic effects and van der Waals forces in the synthesis of organic and inorganic compounds, as well as in design of new crystals and function materials. The proposed book should allow to combine, in a systematic way, recent advances on the application of non-covalent interactions in synthesis and design of new compounds and functional materials with significance in Inorganic, Organic, Coordination, Organometallic, Pharmaceutical, Biological and Material Chemistries. Therefore, it should present a multi- and interdisciplinary character assuring a rather broad scope. We believe it will be of interest to a wide range of academic and research staff concerning the synthesis of new compounds, catalysis and materials. Each chapter will be written by authors who are well known experts in their respective fields.