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It is well established that the tumor microenvironment(TME) plays a pivotal role in tumor initiation, progression and therapeutic resistance by creating a dynamic interaction with cancer cells. TME is comprised of extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels, and non-cancer stromal cells, which serve as a sustained niche for cancer cells to proliferate and metastasize. Notably, various cellular components in TME, including endothelial cells, fibroblasts, pericytes, adipocytes, immune cells, cancer stem cells, and vasculature, could promote tumor’s immune evasion and growth.
This book brings together one hundred and seventy nine selected papers presented at the 2015 International Conference on Design, Manufacturing and Mechatronics (ICDMM2015), which was successfully held in Wuhan, China during April 17-18, 2015.The ICDMM2015 covered a wide range of fundamental studies, technical innovations and industrial applications in advanced design and manufacturing technology, automation and control system, communication system and computer network, signal and image processing, data processing and intelligence system, applied material and material processing technology, power and energy, technology and methods for measure, test, detection and monitoring, applied mechatronics, technology and methods for ship navigation and safety, and other engineering topics.All papers selected here were subjected to a rigorous peer-review process by at least two independent peers. The papers were selected based on innovation, organization, and quality of presentation.The proceedings should be a valuable reference for scientists, engineers and researchers interested in design, manufacturing and mechatronics, as well as graduate students working on related technologies.
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