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Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics
Cancer is a multifactorial chronic disease, in which several factors contribute to its pathogenesis and progression. Our immune system is designed to continuously identify and destroy tumor or aberrant cells. However, a compromised immune system has been associated with the development of cancer. In such immune state, cancer cells often develop the ability to hide from the immune surveillance network and adopt intelligent survival tactics which are continuously developing. Therefore, researchers are focusing on boosting anti-tumor immunity by developing novel cancer immunotherapies. Adoptive cell-based cancer therapies are being used, including in vitro expansion and activation of immune eff...
Emerging Concepts in Bacterial Biofilms
The ability to form biofilms is a universal attribute of bacteria. Bacteria are able to grow on almost every surface, forming these architecturally complex communities. In biofilms, the cells grow in multicellular aggregates, encased in an extracellular matrix produced by the bacteria themselves. They impact humans in many ways, and can form in natural, medical and industrial settings. For example, the formation of biofilms on medical devices such as catheters or implants often results in difficult-to-treat chronic infections. This book focuses on emerging concepts in bacterial biofilm research, such as the different mechanisms of biofilm formation in Gram negative and Gram positive bacteria, and the burden of biofilm associated infections. It also highlights the various anti-biofilm strategies that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants.
Advances in Phytonanotechnology for Treatment of Various Diseases
Several plant bioactives or plant-derived therapeutic molecules have been used against life-threatening diseases and their nanoparticle-mediated delivery greatly improves therapeutic efficacy. Advances in Phytonanotechnology for Treatment of Various Diseases aims to describe past and recent advances achieved in the field of phytonanotechnology. The chapters of this book provide thorough knowledge of medicinal plants, plant bioactives, plant extract-based nanoparticle synthesis, delivery of plant bioactives through nanoparticles, and their therapeutic activity against life-threatening diseases. This book focuses on the therapeutic activity of phytocomponents present in plants from diverse fam...
Muhammad, the Messenger of Islam
Adil writes of the Holy Prophet and how he prayed for mercy upon his enemies. Despite the fact that they did him such harm and caused him so much hurt, he would not curse them, for all prophets' curses instantly take effect.
Sustainable Agriculture in the Era of the OMICs Revolution
Access to food with enough calories and nutrients is a fundamental right of every human. The global population has exceeded 7.8 billion and is expected to pass 10 billion by 2055. Such rapid population increase presents a great challenge for food supply. More grain production is needed to provide basic calories for humans. Thus, it is crucial to produce 60-110% more food to fill the gap between food production and the demand of future generations. Meanwhile food nutritional values are of increasing interest to accommodate industrialized modern lives. The instability of food production caused by global climate change presents another great challenge. The global warming rate has become more ra...
Urdu for Children, Book 1
Urdu for Children is the first comprehensive instructional package for teaching children Urdu as a second language. It includes a two-volume textbook, a workbook for learning the mechanics of Urdu writing, a comprehensive teacher's manual, and an audio cassette. Aimed at North American children between the ages of four and six, Urdu for Children combines traditional and whole-language instructional methods. The two-volume textbook includes forty lessons, each structured around a story or poem that reflects the theme "All About Me." This theme was chosen because children in the primary division show the greatest enthusiasm for things that relate to themselves. The methodology, outlined in the...
