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Black Tudors
Shortlisted for the Wolfson History Prize 2018 A Book of the Year for the Evening Standard and the Observer A black porter publicly whips a white Englishman in the hall of a Gloucestershire manor house. A Moroccan woman is baptised in a London church. Henry VIII dispatches a Mauritanian diver to salvage lost treasures from the Mary Rose. From long-forgotten records emerge the remarkable stories of Africans who lived free in Tudor England… They were present at some of the defining moments of the age. They were christened, married and buried by the Church. They were paid wages like any other Tudors. The untold stories of the Black Tudors, dazzlingly brought to life by Kaufmann, will transform how we see this most intriguing period of history.
Novel Vaccination Strategies
The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.
Mycobacteria and TB
Tuberculosis remains one of the main fatal infections in humans. With annual morbidity and mortality rates worldwide of 8 and 2 million cases respectively, the disease is far from being eradicated. In fact, the dangerous liaison between TB and HIV, and the increasing incidences of multidrug resistant strains of Mycobacterium tuberculosis are aggravating the problem. The latest epidemiological data indicate that new drugs and a novel vaccine are urgently needed to control TB adequately. This volume summarizes the state of the art in the prevention, diagnosis and therapy of TB. In addition, the molecular biology of M. tuberculosis and the immunology of the host response are presented. Research...
Immunology of Infection
Immunology of Infection, 3e, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the microbiologist interested in analyzing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes" and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
Reassessing Twenty Years of Vaccine Development Against Tuberculosis
Tuberculosis (TB) remains the prime bacterial infection worldwide with 10.4 million infections and a death toll of 1.7 million people in 2016 according to WHO statistics. Tuberculosis is caused by members of the Mycobacterium tuberculosis complex, facultative intracellular bacteria able to thrive within otherwise potent innate defense cells, the macrophages. In a world of increasing numbers of infections with drug resistant M. tuberculosis strains, the daunting race between developing new therapeutics and emerging resistant strains will hardly produce a winner. This cycle can only be broken by enhancing population wide immune control through a better vaccine as the only one currently in use,...
The Grand Challenge for the Future
The vaccines most urgently needed are those against poverty-related diseases such as tuberculosis, malaria and HIV. However, there is a considerable gap between the development of a vaccine and the implementation as a useful measure for disease control. Major obstacles need to be overcome even after successful completion of the preclinical stage. This book provides an important link between vaccine development and application under the particular conditions in developing countries. The editors, S.H.E. Kaufmann and P.H. Lambert - one from the field of basic research and the other an expert on the side of applied vaccinology - have gathered contributions from specialists of both fields in an attempt to create a source of information that has thus far not been available.
AIDS and Tuberculosis
Providing the latest information on preventive, diagnostic and therapeutic aspects of tuberculosis and AIDS, this is the only book to place a major emphasis on the increasing coexistence of these two life-threatening diseases in individuals. Edited by outstanding scientists in the field, this ready reference is divided into three main sections covering immunology and vaccination strategies, drugs, and clinical issues. Timely reading for microbiologists, virologists, bacteriologists, immunologists, and pathophysiologists, as well as for the pharmaceutical and biotechnological industries.
T-Cell Paradigms in Parasitic and Bacterial Infections
It has been said that the development of vaccines against a variety of infectious diseases is among the greatest triumphs of immunology. Indeed, several pathogens have lost their horror through the availability of effective vaccination measures. Unfortunately, this does not hold true for the pathogens dealt within this volume. Malaria, schistosomiasis, leishmaniasis, leprosy, and tuberculosis together are prevalent in more than 100 countries, and over 400 million persons suffer from these diseases. It is becoming increasingly clear that the failure to control these infections in a satisfactory way is directly related to the complexity oftheir interactions with the immune system. These agents...
The New Plagues
The threat from infectious diseases has increased with globalization. Throughout the history of mankind, epidemics have eradicated whole regions, started the migration of peoples and decided wars. They continue to leave their mark on societies, as well as influencing politics and economies. The New Plagues: Pandemics and Poverty in a Globalized World explores the strategies of microbes in conjunction with the economic impact of epidemics. In particular, it looks at the conflict between rich and poor with regard to outbreaks, and introduces possible strategies for containment.
Kaufmann's
In 1868, Jacob Kaufmann, the nineteen-year-old son of a German farmer, stepped off a ship onto the shores of New York. His brother Isaac soon followed, and together they joined an immigrant community of German Jews selling sewing items to the coal miners and mill workers of western Pennsylvania. After opening merchant tailor shops in Pittsburgh’s North and South sides, the Kaufmann brothers caught the wave of a new type of merchandising—the department store—and launched what would become their retail dynasty with a downtown storefront at Fifth Avenue and Smithfield Street. In just two decades, Jacob and his brothers had ascended Pittsburgh’s economic and social ladder, rising from ha...
