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Single-cell analysis on the pathophysiology of autoimmune diseases
Despite increasing research to facilitate the understanding of the pathophysiology of autoimmune disorders, the exact cause of the incident of autoimmunity is unknown. Current concepts on the occurrence of autoimmune diseases are thought to involve autoantigens, genetic predisposition, disease triggers, and the breakdown of immune tolerance. In addition to the breakdown of immunological tolerance, one key characteristic of autoimmune disease is that within a single disease there is considerable variability in the clinical manifestation and severity in patients. Single-cell omics have emerged as an effective means of unraveling the complexity and heterogeneity of chronic disease development and therapeutic responses. Recently, advances in cutting-edge spatial profiling of diverse cell types have increased our understanding of how distinct cells interact and orchestrate at specific locations across a tissue landscape in both physiological and pathological contexts at the single-cell level.
Current Progress in Genomic and Genetic Research on Human Viral Diseases
Viral diseases pose a severe threat to public health globally with many pathogenic viruses circulating, and many more might be yet to emerge. Viral infections have become an inevitable event in our daily lives however people may not know much about their causal pathogens. The ongoing pandemic of the coronavirus disease 2019 (COVID-19) raises another alarm that our fight against viral pathogens is far from ending, and our understanding of the complex interactions between the viral invaders and the human host remains limited.
B Cell Protocols
B-lymphocyte development and function remains an exciting area of research for those interested in the physiology and pathology of the immune system in higher animals. While recent advances in genetics and cellular and molecular biology have provided a large spectrum of powerful new experimental tools in this field, it is both time consuming and often very difficult for a student or just any bench-side worker to identify a reliable experimental protocol in the ocean of the literature. The aim of B Cell Protocols is to provide a collection of diverse protocols ranging from the latest inventions and applications to some classic, but still frequently used methods in B-cell biology. The authors ...
Handbook of ELISPOT
In this first book dedicated entirely to the ELISPOT, a critical enzyme-linked immunospot assay used widely in biomedical research, recognized experts with first-hand experience detail how to design, perform, and analyze these assays. The readily reproducible techniques they provide cover a wide variety of topics, including the use of membrane-backed plates, the standardization and validation procedures, the removal of cells from ELISPOT plates, cell separation techniques, and the quantification of ELISPOT data. There are also numerous ELISPOT applications involving animal models, human cells, measles, multiple sclerosis, immune responses, multicytokine detection systems, and immunocytochemistry. Highlights include dual-color and multiplex ELISPOT assays, use of the ELISPOT assay on feline lymphocytes, standardization of the ELISPOT procedure, and combining the ELISPOT assay with immunohistochemistry.
Digital Image Forensics
Photographic imagery has come a long way from the pinhole cameras of the nineteenth century. Digital imagery, and its applications, develops in tandem with contemporary society’s sophisticated literacy of this subtle medium. This book examines the ways in which digital images have become ever more ubiquitous as legal and medical evidence, just as they have become our primary source of news and have replaced paper-based financial documentation. Crucially, the contributions also analyze the very profound problems which have arisen alongside the digital image, issues of veracity and progeny that demand systematic and detailed response: It looks real, but is it? What camera captured it? Has it...
Innovative Mobile and Internet Services in Ubiquitous Computing
This book presents the latest research findings, methods and development techniques related to Ubiquitous and Pervasive Computing (UPC) as well as challenges and solutions from both theoretical and practical perspectives with an emphasis on innovative, mobile and internet services. With the proliferation of wireless technologies and electronic devices, there is a rapidly growing interest in Ubiquitous and Pervasive Computing (UPC). UPC makes it possible to create a human-oriented computing environment where computer chips are embedded in everyday objects and interact with physical world. It also allows users to be online even while moving around, providing them with almost permanent access to their preferred services. Along with a great potential to revolutionize our lives, UPC also poses new research challenges.
Cosmology and Particle Astrophysics
Beginning with basic facts about the observable universe, this book reviews the complete range of topics that make up a degree course in cosmology and particle astrophysics. The book is self-contained - no specialised knowledge is required on the part of the reader, apart from undergraduate math and physics. This paperback edition targets students of physics, astrophysics and cosmology from advanced undergraduate to early graduate level.
