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Negative Regulators of Innate Immunity and their Role in Host Responses to Injury and Infection, 2nd edition
Every organism must recognize damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs) to react rapidly. The immune system requires potent negative regulators to control unnecessary or overshooting responses and balance the homeostasis in all tissues. A significant number of negative regulators of pattern recognition receptors (PRR) consist of modified innate sensors and downstream molecules that regulate inflammatory signals initiated by sterile, damage-associated inflammation as well as responses to pathogens. These conserved mechanisms contribute to immune homeostasis, maintain a constant number of immune cells, and limit the activation of the cells during frequent s...
Neutrophil Extracellular Traps
Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.
Cholesterol Crystals in Atherosclerosis and Other Related Diseases
This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid’ cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book exa...
Reviews of Physiology, Biochemistry and Pharmacology
Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses
Nano- and microparticles including crystals, synthetic biomaterials, misfolded proteins or environmental particulates are involved in a wide range of biological processes and diseases. They may present as intrinsic or environmental toxins but may also be applied intentionally, e.g. as immune adjuvants, drug carriers or ion exchangers. The discovery that a wide range of nano- and microparticles share the capacity to induce IL-1β secretion via activation of the NLRP3 inflammasome in dendritic cells and macrophages has led to the hypothesis that nano- and microparticles may contribute in a uniform mechanistic manner to different disease entities. Other molecular mechanisms triggered by a range...
Toxic Superfoods
An acclaimed nutrition educator reveals how the foods you’re eating to get healthy might be making you sick. “Sally Norton’s well-researched book makes a truly important contribution to the literature in revealing just how much oxalates can damage the human body.”—Nina Teicholz, author of The Big Fat Surprise If you’re eating a healthy diet and you’re still dealing with fatigue, inflammation, anxiety, recurrent injuries, or chronic pain, the problem could be your spinach, almonds, sweet potatoes, and other trusted plant foods. And your key to vibrant health may be quitting these so-called superfoods. After suffering for decades from chronic health problems, nutrition educator S...
Inflammation, 4 Volume Set
Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
NETosis: At the Intersection of Cell Biology, Microbiology, and Immunology
NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflamma...
