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Twenty years ago when Children's Cancer Association of Japan was born, the diagnosis of childhood leukemia amounted to a death sentence. Only 20% or so of children with leukemia survived more than 5 years. Since then, enormous improvements have been achieved regarding our understanding on the etiology, diagnosis, and the treatment of childhood leukemia. Now, 70% of children with leukemia survive and enter adult life. Even though the improved survival rate of children with leukemia represents a medical success story, we now face new problems. The first problem is the fact that we still lose 20-30% of patients with childhood leukemia. To address this problem, we need to understand the etiology...
This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Several processes are presumed to sequentially or simultaneously contribute to the pathophysiology of multiple sclerosis (MS). This work examines the potential of biomarkers in the context of MS. It explores the state of biomarker research for MS, barriers to progress and possible solutions and priorities.
Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie, Hamburg, June 27/28, 1986
You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation funct...
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