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The LAFLIN family have been found in Suffolk since the mid sixteenth century until the present day. This book represents the current state of my research into their history and takes it from around 1500 (the earliest reference yet found is 1524) to the 1901 census. Throughout the discussion, I have tried to indicate my sources so that readers may check the information and form their own opinions. This book was first printed in 2007. I had hoped to produce an updated version including information from the 1911 census, but other demands on my time have made this impossible so far. Until such a book is possible, I have decided to make this 2007 version publicly available.
This book provides, for the first time, a broad and deep treatment of the fields of both ultra low power electronics and bioelectronics. It discusses fundamental principles and circuits for ultra low power electronic design and their applications in biomedical systems. It also discusses how ultra energy efficient cellular and neural systems in biology can inspire revolutionary low power architectures in mixed-signal and RF electronics. The book presents a unique, unifying view of ultra low power analog and digital electronics and emphasizes the use of the ultra energy efficient subthreshold regime of transistor operation in both. Chapters on batteries, energy harvesting, and the future of energy provide an understanding of fundamental relationships between energy use and energy generation at small scales and at large scales. A wealth of insights and examples from brain implants, cochlear implants, bio-molecular sensing, cardiac devices, and bio-inspired systems make the book useful and engaging for students and practicing engineers.
Transformation from Wall Street to Well-being: Joining up the dots through Participatory democracy and governance to mitigate the causes and adapt to the effects of climate change addresses accountable leadership, supports collective interests, ethical governance and fairness to future generations in order to develop systemic approaches relevant to these issues. The humanistic focus, whilst central, addresses how we see ourselves in relation to the environment. It explores cultural perspectives in developed and developing parts of the world where people have a closer connection with the natural environment in comparison to those who live in cities. Furthermore the book discusses participator...
Two distinguished neuroscientists distil general principles from more than a century of scientific study, “reverse engineering” the brain to understand its design. Neuroscience research has exploded, with more than fifty thousand neuroscientists applying increasingly advanced methods. A mountain of new facts and mechanisms has emerged. And yet a principled framework to organize this knowledge has been missing. In this book, Peter Sterling and Simon Laughlin, two leading neuroscientists, strive to fill this gap, outlining a set of organizing principles to explain the whys of neural design that allow the brain to compute so efficiently. Setting out to “reverse engineer” the brain—dis...
Work as fundamental to life, explored at different levels of organization from the perspectives of a variety of biological and nonbiological disciplines.
An understanding of the senses - vision, hearing, touch, chemical and other non-human senses - is important not only for many fields of biology but also in applied areas such as human-computer interaction, robotics and computer games. Using information theory as a unifying framework, this is a wide-ranging survey of sensory systems, covering all known senses. The book draws on three unifying principles to examine senses: the Nyquist sampling theorem, Shannon's information theory, and the creation of different streams of information to subserve different tasks. This framework is used to discuss the fascinating role of sensory adaptation in the context of environment and lifestyle. Providing a fundamental grounding in sensory perception, the book then demonstrates how this knowledge can be applied to the design of human-computer interfaces and virtual environments. It is an ideal resource for both graduate and undergraduate students of biology, engineering (robotics) and computer science.
Learn the fundamentals of information theory, including entropy, coding, and data compression, while exploring advanced topics like transfer entropy, thermodynamics, and real-world applications. Key Features A clear blend of foundational theory and advanced topics suitable for various expertise levels A focus on practical examples to complement theoretical concepts and enhance comprehension Comprehensive coverage of applications, including data compression, thermodynamics, and biology Book DescriptionThis book offers a comprehensive journey through the fascinating world of information theory, beginning with the fundamental question: what is information? Early chapters introduce key concepts ...
The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to u...
Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically or...