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Flavonoids and Phenolics
Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be transla...
Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis
The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility
Terpenes
Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson’s disease and Alzheimer’s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Advances in Chemical Analysis Procedures (Part I)
The availability (and the development) of innovative approaches to quantitative analyses and the data processing are often mandatory to deeply characterize a sample and to correctly highlight the analytical target. These objectives are carried out either by simply improving a single aspect of the analytical protocol or by developing a synergy of steps (from extraction to instrumental configuration to chemometric approaches) to obtain the maximum analytical information sought. Examples are innovative extraction protocols (also following the recent guidelines on green analytical chemistry) or new materials for the selective extraction of target compounds, multi-analytes screening methods, and ...
Metalloenzymes
Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. - Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design - Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application - Features chapter contributions from international experts in the field
Tyrosinase
Tyrosinase, Volume 56 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on tyrosinases (genetics, molecular biology, phylogenetic relationship), Catalytic mechanism of tyrosinases, Structural characterization of tyrosinases, Assay methods of tyrosinase activity and inhibition, Natural products as tyrosinase inhibitors, Drug design of tyrosinase inhibitors, Peptide and peptidomimetic tyrosinase inhibitors, Computational studies of tyrosinase inhibitors, Bacterial tyrosinases and their inhibitors, and Biomedical applications of tyrosinases and tyrosinase inhibitors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series - Highlights new advances on Tyrosinase
Bacterial Carbonic Anhydrases
Bacterial Carbonic Anhydrases, Volume 55 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on bacterial CA genetic families, Bacterial a-CAs, Bacterial ß-CAs, Bacterial ?-CAs, Bacterial ?-CAs, Sulfonamide bacterial CA inhibitors, Non-sulfonamide bacterial CA inhibitors, Helicobacter pylori CA inhibition, Neisseria gonorrhea CA inhibition, Vancomycin resistant enterococci CA inhibition, Pseudomonas aeruginosa CA inhibition, Mycobacterium tuberculosis CA inhibition, and Challenges for developing bacterial CA inhibitors as novel antibiotics. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series - Highlights new advances on bacterial carbonic anhydrases
Advances in Prodrugs
Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodr...
Plant-derived Bioactives
Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bio...
Therapy Resistance in Prostate Cancer
Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies. Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pat...
