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ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era
Professor Hang Fai Kwok has two filed patents on ADAM17 antibody applications in cancer and cardiovascular disease. All other Topic Editors declare no competing interests with regards to the Research Topic.
Biology of Mesenchymal Stromal Cells -Emerging New Concepts to Improve Function and Scalability
Human mesenchymal stromal cells (MSCs) can be harvested from many tissues, including bone marrow (BM), cord blood (CB), adipose tissue, umbilical cord (UC), placenta and others. In recent years, there has been an overwhelming interest in MSC as reflected in the number of reports regarding their characterization, biological properties and clinical application. One of the specific areas of research involves the characterization of MSCs derived from different sources as well as the potential differences between them. More recently, reports have been published on derivatives from MSCs such as extracellular vesicles (EVs)/exosomes and mitochondria, but their characterization, mechanisms of action in immunomodulatory functions and regeneration aspects have not been fully elucidated.
Modern Charge-Density Analysis
Focusing on developments from the past 10-15 years, this volume presents an objective overview of the research in charge density analysis. The most promising methodologies are included, in addition to powerful interpretative tools and a survey of important areas of research.
Activity-Based Protein Profiling
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Multi-Component Crystals
In this volume, contributions covering the theoretical and practical aspects of multicomponent crystals provide a timely and contemporary overview of the state-of-the art of this vital aspect of crystal engineering/materials science. With a solid foundation in fundamentals, multi-component crystals can be formed, for example, to enhance pharmaceutical properties of drugs, for the specific control of optical responses to external stimuli and to assemble molecules to allow chemical reactions that are generally intractable following conventional methods. Contents Pharmaceutical co-crystals: crystal engineering and applications Pharmaceutical multi-component crystals: improving the efficacy of a...
The Archaeology of Childhood
Children existed in ancient times as active participants in the societies in which they lived and the cultures they belonged to. Despite their various roles, and in spite of the demographic composition of ancient societies where children comprised a large percentage of the population, children are almost completely missing in many current archaeological discourses. To remedy this, The Archaeology of Childhood aims to instigate interdisciplinary dialogues between archaeologists and other disciplines on the notion of childhood and children and to develop theoretical and methodological approaches to analyze the archaeological record in order to explore and understand children and their role in ...
Understanding Complexity
Peter A. Coming Palo Alto, CA November, 2000 This volwne represents a distillation of the plenary sessions at a unique millenniwn year event -a World Congress of the Systems Sciences in conjunction with the 44th annual meeting of the International Society for the Systems Sciences (ISSS). The overall theme of the conference was "Understanding Complexity in the New Millenniwn. " Held at Ryerson Polytechnic University in Toronto, Canada, from July 16-22,2000, the conference included some 350 participants from over 30 countries, many of whom were representatives of the 21 organizations and groups that co-hosted this landmark event. Each of these co-host organizations/groups also presented a segm...
Renaissance Woman
A biography of Vittoria Colonna, a confidante of Michelangelo, the scion of one of the most powerful families of her era, and a pivotal figure in the Italian Renaissance Ramie Targoff’s Renaissance Woman tells of the most remarkable woman of the Italian Renaissance: Vittoria Colonna, Marchesa of Pescara. Vittoria has long been celebrated by scholars of Michelangelo as the artist’s best friend—the two of them exchanged beautiful letters, poems, and works of art that bear witness to their intimacy—but she also had close ties to Charles V, Pope Clement VII and Pope Paul III, Pietro Bembo, Baldassare Castiglione, Pietro Aretino, Queen Marguerite de Navarre, Reginald Pole, and Isabella dâ...
Discrete Tomography
Goals of the Book Overthelast thirty yearsthere has been arevolutionindiagnostic radiology as a result oftheemergenceofcomputerized tomography (CT), which is the process of obtaining the density distribution within the human body from multiple x-ray projections. Since an enormous variety of possible density values may occur in the body, a large number of projections are necessary to ensure the accurate reconstruction oftheir distribution. There are other situations in which we desire to reconstruct an object from its projections, but in which we know that the object to be recon structed has only a small number of possible values. For example, a large fraction of objects scanned in industrial...
