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Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clinical decision-making. Structured in a jargon-free question-and-answer format, each chapter provides concise and understandable information on a different aspect of randomized controlled trials, from the basics of trial design and terminology to the interpretation of results and their use in driving evidence-based medicine. The authors end each chapter with their musings, going beyond the evidence or citations, and sometimes even beyond orthodox correct...
Everyday, we come into contact with many relatively harmless substances that could, at certain concentrations, be toxic. This applies not only to obvious candidates such as asbestos, lead, and gasoline, but also to compounds such as caffeine and headache tablets. While the field of toxicology has numerous texts devoted to aspects of biology, chemis
This book brings together in one volume fifteen discoveries that have had a major impact upon medical science and the practice of medicine but where the scientists involved have not been awarded a Nobel Prize. Its aim is to publicize the achievements of these lesser-known heroes of our time and thereby inform and entertain the reader, whether medical student, professor or scientifically-minded layman.
At the end of the Second World War, Britain had the highest incidence of lung cancer in the world. For the first time lung cancer deaths exceeded those from tuberculosis - and no one knew why. On 30 September 1950, a young physician named Richard Doll concluded in a research paper that smoking cigarettes was 'a cause and an important cause' of the rapidly increasing epidemic of lung cancer. His historic and contentious finding marked the beginning of a life-long crusade against premature death and the forces of 'Big Tobacco'. Born in 1912, Doll, a natural patrician, jettisoned his Establishment background and joined the Communist Party as a reaction to the 'anarchy and waste' of capitalism i...
Written by leading statisticians and probabilists, this volume consists of 104 biographical articles on eminent contributors to statistical and probabilistic ideas born prior to the 20th Century. Among the statisticians covered are Fermat, Pascal, Huygens, Neumann, Bernoulli, Bayes, Laplace, Legendre, Gauss, Poisson, Pareto, Markov, Bachelier, Borel, and many more.
Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline