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For the last few decades researchers from different fields gather their findings and knowledge trying to give a shape to the new science of complex systems. To address this problem, new tools and methods have to be established. A new, or more precisely an alternative, framework for the characterization of complex system was proposed. In this book we will introduce the applicability of applicability of simplicial complexes in the science of complex systems. After introducing the main definitions and properties of simplicial complexes necessary for representation and analysis of complex systems, we will illustrate the usefulness and versatility of tools and concepts related to the simplicial complexes.
The three-volume set LNCS 5101-5103 constitutes the refereed proceedings of the 8th International Conference on Computational Science, ICCS 2008, held in Krakow, Poland in June 2008. The 167 revised papers of the main conference track presented together with the abstracts of 7 keynote talks and the 100 revised papers from 14 workshops were carefully reviewed and selected for inclusion in the three volumes. The main conference track was divided into approximately 20 parallel sessions addressing topics such as e-science applications and systems, scheduling and load balancing, software services and tools, new hardware and its applications, computer networks, simulation of complex systems, image...
Though the reductionist approachto biology and medicine has led to several imp- tant advances, further progresses with respect to the remaining challenges require integration of representation, characterization and modeling of the studied systems along a wide range of spatial and time scales. Such an approach, intrinsically - lated to systems biology, is poised to ultimately turning biology into a more precise and synthetic discipline, paving the way to extensive preventive and regenerative medicine [1], drug discovery [20] and treatment optimization [24]. A particularly appealing and effective approach to addressing the complexity of interactions inherent to the biological systems is provided by the new area of c- plex networks [34, 30, 8, 13, 12]. Basically, it is an extension of graph theory [10], focusing on the modeling, representation, characterization, analysis and simulation ofcomplexsystemsbyconsideringmanyelementsandtheirinterconnections.C- plex networks concepts and methods have been used to study disease [17], tr- scription networks [5, 6, 4], protein-protein networks [22, 36, 16, 39], metabolic networks [23] and anatomy [40].
This book provides an accessible yet rigorous introduction to topology and homology focused on the simplicial space. It presents a compact pipeline from the foundations of topology to biomedical applications. It will be of interest to medical physicists, computer scientists, and engineers, as well as undergraduate and graduate students interested in this topic. Features: Presents a practical guide to algebraic topology as well as persistence homology Contains application examples in the field of biomedicine, including the analysis of histological images and point cloud data
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