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Metal Compounds in Cancer Therapy
The discovery of the antitumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major international research effort investigating the potential of metal compounds in cancer therapy. Cisplatin now occupies an important place in the armamentarium of the oncologist due to its effectiveness in the treatment of testicular cancer. A second generation analogue, carbo platin, offers reduced toxicity together with therapeutic activity, which gives it a place in the front-line therapy of genitourinary cancers. These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that met...
Metal Compounds in Cancer Therapy
The discovery of the anti-tumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major research effort into the potential of metal compounds in cancer therapy. This book draws together information on all metals involved in cancer therapy, including those used in radioisotopes. Throughout an interdisciplinary approach has been taken to reflect the nature of this research. This book will provide an invaluable reference source for anyone interested in the role of metals in oncotherapy.
Metal Ions in Biological Systems
Metal ions are currently used for such applications as diabetes, anti-inflammatory, rheumatoid arthritis, psychiatric, and anti-ulcer medications, using compounds of vanadium, copper and zinc, gold, lithium, and bismuth, respectively. This text explores these applications in addition to an assessment of chelation therapy, uses in environmental scie
Child-Friendly Perspectives on Gender and Sexual Diversity
This book discusses LGBTI+ childhood from a critical, interdisciplinary perspective with the aim of contributing to a better understanding of the complex relationship between sexuality, gender and childhood. Placing adultcentrism at the centre of the analytical inquiry, the international range of contributors consider experiences and subjectivities of children, their families and significant contexts. Topics covered include public policies, professional practices and care provision, as well as the tensions and contradictions stemming from the logics of otherness and exceptionality which populate dominant discourses, representations and practices around sex and gender in childhood. This book is intended for researchers and students in gender studies, sexuality studies, education, health, childhood studies and sociology.
Exploration of Subsurface Antarctica
Our appreciation of glaciological processes in Antarctica suffers from a lack of observations in regions where numerical models indicate the ice sheet to be susceptible to ocean and/or atmospheric warming. The solution lies in the use and development of glacier geophysics. In this volume we present a series of papers that demonstrate how geophysics can be deployed in Antarctica to comprehend: (1) boundary conditions that influence ice flow such as subglacial topography, the distribution of basal water and ice-sheet rheology; (2) phenomena that might affect ice-flow processes, such as complex internal ice-sheet structures and the proposition of large stores of hitherto unappreciated groundwater; and (3) how glacigenic sediments and formerly glaciated terrain on, and surrounding, the continent can inform us about past ice-sheet dynamics. The volume also takes a historical view on developments leading to current knowledge, examines active ice-sheet processes, and points the way forward on how geophysics can advance quantitative understanding of Antarctic ice-sheet behaviour.
Peptide Hydrolases—Advances in Research and Application: 2012 Edition
Peptide Hydrolases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Peptide Hydrolases. The editors have built Peptide Hydrolases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peptide Hydrolases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Peptide Hydrolases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Nitric Oxide Donors
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
