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The Nidoviruses
This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases. The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting. This represents the only comprehensive book to cover this field in the last five years.
Viral Entry into Host Cells
For a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism. The multi-faceted interplay between viral and cellular factors during virus entry is a fascinating field of study, which can provide important insight into viral pathogenesis and define new targets for intervention. This book provides a comprehensive overview of this exciting field of research.
New Concepts of Antiviral Therapy
Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.
Cellular and Molecular Control of Neuronal Migration
Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.
Ecological Genomics
Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from t...
Receptor-independent/-associated viral tropism
One of the most important and outstanding characteristics of viruses is their cellular and host tropism. As parasitic entities, viruses have to compromise with numbers of positive and negative factors present in target cells for their survival. In the absence of an appropriate interaction with cells, they do not replicate at all. Viral tropism can be therefore determined at each replication step, from the entry to progeny production in target cells. There are two major types of viral tropism, that is, the receptor-dependent and -independent tropisms. Restriction of viral replication occurs on the cell surface (receptor-dependent viral entry step) and/or intracellularly (receptor-independent ...
The Gene Editors
Susie Miller, a 40-something Life Sciences lawyer unwittingly stumbles into the murky and dangerous global biotechnology arms-race and the struggle to control its power and wealth. She takes readers through an eye-opening journey of discovery and intrigue through the complex and secretive world of gene-editing. Her fascination with the creation of the world’s first gene-edited babies in 2018 triggers alarm bells. Her research quickly sparks interest from the military, governments, private entities and various intelligence services which intensifies as the global Covid-19 pandemic unfolds. Susie’s specific paradigm in understanding the bigger picture begins to unlock the secrecy and obfus...
Activation of Viruses by Host Proteases
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
Molecular Biology of the SARS-Coronavirus
SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species o...
Are We the Next Endangered Species?
Are We the Next Endangered Species? unravels the complex web of historical events, misinformation, and the ominous convergence of bioweapons and eugenics In this thought-provoking new book, Dr. Fleming challenges us to navigate the murky waters of history, exposing parallel programs developed over the last 170 years in the United States. This riveting exploration unearths ancient civilizations that embraced slavery, sterilization, and eugenics, drawing chilling parallels to our present reality. Dr. Fleming confronts the uncomfortable truth: are we repeating the mistakes of the past while expecting different outcomes? Are we destined to replicate the errors that led to the rise of powerful in...
