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Effects of Iodine Intake on Human Health
Iodine, a key component of thyroid hormones, is considered an essential micronutrient for proper health at all life stages. Indeed, an inadequate dietary intake of iodine is responsible for several functional and developmental abnormalities. The most serious consequences of iodine deficiency include hypothyroidism, early abortion, low birth weight, preterm delivery, neurocognitive impairment, and mental retardation. On the other hand, the consequences of mild-to-moderate iodine deficiency, such as goiter, are less well understood but represent an important priority for research and public health practice. Over the last several decades, many countries across the globe have introduced mandatory salt iodization programs, which have dramatically reduced the number of iodine-deficient countries. However, despite substantial progress worldwide, mild-to-moderate deficiency is still prevalent even in many developed countries. Thus, the ongoing monitoring of the population iodine status remains crucially important, and attention may need to be paid to vulnerable life stage groups.
In Silico Methods for Drug Design and Discovery
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Mechanisms of Adiponectin Action
The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin ha...
Cancer Research
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Crustumerium
This volume is the first of the series Corollaria Crustumina aimed at the publication of conference proceedings, doctoral theses and specialist studies on the Latin settlement of Crustumerium (Rome). It contains multidisciplinary papers of an international group of archaeologists discussing new fieldwork data on Crustumeriums settlement, cemeteries and material culture in light of the sites cultural identity.
L’odio nascosto
Daniela Girlandi è in fuga in Messico. Dopo essere sfuggita miracolosamente all’arresto dell’Fbi, la donna ha in mente una sola cosa: la vendetta. L’avidità e la brama di potere l’hanno portata a rischiare nel commercio illegale di farmaci, in combutta con un dirigente della Longlife Chemicals. Ora quella parentesi è chiusa ma non è da Daniela, che anela a un protagonismo assoluto, accontentarsi di una vita di basso profilo, sia pure agiata. Stefano, l’uomo che ha tentato di uccidere e con il quale ha avuto una fugace storia d’amore, non potrà dormire sonni tranquilli. Quella donna si rifarà viva per giocare crudelmente con l’esistenza di altre vite umane. E per farlo sar...
Advances in Cryptology - ASIACRYPT 2002
This book constitutes the refereed proceedings of the 8th International Conference on the Theory and Application of Cryptology and Information Security, ASIACRYPT 2002, held in Singapore, in December 2002. The 34 revised full papers presented together with two invited contributions were carefully reviewed and selected from 173 submissions on the basis of 875 review reports. The papers are organized in topical sections on public key cryptography, authentication, theory, block ciphers, distributed cryptography, cryptanalysis, public key cryptanalysis, secret sharing, digital signatures, applications, Boolean functions, key management, and ID-based cryptography.
