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If you live life without a net, what happens when you fall? Kathleen Cremonesi knew early on she wanted to be different. Determined to avoid following in her mother's footsteps to an ill-fated marriage, Kathleen left Oregon in her early 20s to travel across Europe. On a whim, this former administrative assistant with wanderlust took a job as a dancer in a circus and, working her way up, became an ostrich-riding, shark-taming showgirl. Kathleen bonds with the exotic animals that could strike and kill at any moment, but instead bring her a peace she has never known. And when she stumbles into the arms of Stefano, the sexy elephant keeper, she finds a man who understands her wild spirit. With thrilling prose and vivid descriptions, Kathleen takes the reader around the Mediterranean, where she discovers unexpected friends and learns how to cook, forgive, and love - across language barriers.
Tumor necrosis factor receptor (TNFR) associated factors (TRAFs) are a family of signaling adaptors first identified as components of TNFR signaling complexes, but now recognized to regulate signal transduction downstream of a diverse array of receptors, including Toll like receptors, antigen receptors and cytokine receptors. TRAF proteins play important roles in many human diseases and processes as both positive and negative regulators. This eBook begins with a review of TRAF structure, followed by reviews on the role of TRAFs in NF-kB and mitogen activated protein kinase (MAPK) signaling as well as in signaling downstream of innate pattern recognition receptors. Next is a review focused on...
Over recent years, native pentameric C-reactive protein (pCRP) and its biologically active dissociated form, monomer monomeric CRP (mCRP) have assumed an important role in disease development and pathophysiology. In this series, we have highlighted the thoughts and research of the most eminent scientists in the field of CRP research. This eBook is a collection of original articles and reviews on the subject, creating an archive of current knowledge and understanding. This Research Topic provides new findings of the role of CRP in the fields of neuroscience, cardiovascular disease, inflammation, and macular degeneration as well as defined links to stages in pathological disease progression. These articles explain the mechanisms and pathways through which the dissociated mCRP interacts with a variety of cells, and provide possible prognostic implications and new methods for analysis. Over the coming years, the importance and fascination of the active role of CRP in health and disease is set to rise, and we hope this collection will serve as a valuable reference for these future investigations.
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