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Animal Cell Electroporation and Electrofusion Protocols
The ability to introduce macromolecules into animal cells, includ ing DNA, RNA, proteins, and other bioactive compounds has facili tated a broad range of biological studies, from biochemistry and biophysics to molecular biology, cell biology, and whole animal stud ies. Gene transfer technology in particular will continue to play an essential role in studies aimed at improving our understanding of the relationships between the gene structure and function, and it has impor tant practical applications in both biotechnology and biomedicine, as evidenced by the current intense interest in gene therapy. Although DNA and other macromolecules may be introduced into cells by a variety of methods, inc...
Yeast Systems Biology
Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies ...
Data-Centric Biology
In recent decades, there has been a major shift in the way researchers process and understand scientific data. Digital access to data has revolutionized ways of doing science in the biological and biomedical fields, leading to a data-intensive approach to research that uses innovative methods to produce, store, distribute, and interpret huge amounts of data. In Data-Centric Biology, Sabina Leonelli probes the implications of these advancements and confronts the questions they pose. Are we witnessing the rise of an entirely new scientific epistemology? If so, how does that alter the way we study and understand life—including ourselves? Leonelli is the first scholar to use a study of contemp...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Methods in Systems Biology
Systems biology is a term used to describe a number of trends in bioscience research and a movement that draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology. With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research
Trainees and Fellows Supported by the National Institute of Dental Research and Trained During Fiscal Year
Separate listings of trainees and fellows given grants and awards. Intended to identify young scientists who may be recruited for work in dental research by administrators and investigators. Contains 6 sections comprising listings of 2 groups by names, by major disciplines, and by dates of receipt of degrees. Entries include name, discipline, degrees and dates, year of birth, program director, and grant number.
Fungal Genomics
The volume is divided into four sections, the first of which, Genome Sequences and Beyond, illustrates the impact of genome-based information and techniques on research ranging from model organisms like yeast to less-studied basal fungal lineages. Furthermore, it highlights novel types of analysis made possible by multi-genome comparisons as well as the impact of genomics on culture collections and vice versa. The second section, Cell and Developmental Biology, addresses questions that are important for fungal biology, e.g. the development of fungal fruiting bodies, and biology in general, e.g. chromatin organization and circadian rhythms. The third section, Genomics for Biotechnology, covers the search for plant biomass-converting enzymes in fungal genomes and work with industrially important fungi. The fourth section, focusing on Pathogenicity, offers chapters on the genomic analysis of plant and animal/human pathogens. It illustrates how genomics at all levels, from genome to metabolome, is used to study mechanisms of the interactions of fungi with other organisms.
