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Evidence-Based Endocrinology
Internationally recognized experts, pioneers, and opinion makers in evidence-based medicine (EBM) provocatively recast endocrine policy and practice in the light of EBM philosophy and principles. The authors explain the past, present, and future of EBM; consider its practical implications for endocrinology; demonstrate what the "evidence base" is in EBM; and present illustrative case studies by practicing evidence-based clinicians. Highlights include essays on why cost-effective analyses are problematic, the contrast between clinical investigations and large randomized trials, the role of Cochrane reviews and meta-analyses, and the curriculum requirements for training evidence-based endocrinologists.
Stem Cells in Endocrinology
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
Pediatric Endocrinology
An up-to-date and concise guide to the clinical management of pediatric endocrine disorders. The text covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages.
Controversies in Treating Diabetes
This book addresses diabetes controversies, specifically in the management of etiology and the disease itself. Chapters also examine the complications associated with diabetes. The volume covers commonly accepted forms of therapies and complications, as well as new and emerging advances and therapies and inadequacies in several standard treatments. Comprehensive and timely, this book is an essential reference for those treating and researching diabetes.
Treatment of the Obese Patient
The aim of this book is to inform clinicians of recent advances in obesity research and provide a review of current treatment issues and strategies. Part 1 covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Part 2 covers a range of issues that are central to the clinical management of obese patients. This illustrated volume will stimulate and engage clinicians.
Genomics in Endocrinology
Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.
Regents' Proceedings
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The Tools of Science
This book aims to provide useful tips for the understanding of scientific research processes and practical advice for people engaged in this field. It is a reflection of the author's more than 40 years of experience in medical and cancer research, and is written in a colloquial style to reach not only the young audience who are considering devoting their lives to biomedical research, but also to those who are already engaged in this field. The author emphasizes the unique traits and qualifications required for performing scientific research and also describes the different modalities which can be performed in our actual scientific environment. There are numerous practical advices in this book, such as guidelines on writing a grant proposal and the first peer-reviewed manuscript, the selection criteria of the training laboratory and mentors, as well as keeping records of experimental data. The author also provides his insight on the personal inner drive and motivation critical for conducting scientific research, as well as the importance of working on a problem without losing the human perspective of this specific and unique human endeavor.
Methods in Mammary Gland Biology and Breast Cancer Research
approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who ...
