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Drosophila: A Toolbox for the Study of Neurodegenerative Disease
Drosophila gives an overview of the ways in which Drosophila is currently being used as a model organism to further our understanding of a spectrum of human neurological diseases. Each chapter is written by respected researchers and gives an excellent account of the subject that is suitable for postgraduate and postdoctoral researchers.
The Disordered Mind
Neurological and psychiatric disorders have long been regarded as fundamentally different, depending on whether they appear to affect the brain or the mind. In reality, the brain and the mind are inseparable. Both types of disorder can affect every aspect of brain function: from perception, action, memory and emotion to empathy, social interaction, attention and consciousness. It is easy to view brain disorders as simply tragic or frightening. However, studying where these functions go wrong provides a window on the workings of the healthy brain, and makes it more likely that scientists and clinicians will be able to develop effective treatments or preventative strategies. As individuals, and as a society, we are also able to better empathise with people with disorders of the mind. Building on his pioneering research, Eric R. Kandel illustrates how breakthrough studies of brain disruptions can deepen our understanding of thought, feeling, behaviour, memory and creativity, and perhaps in the future will transform medical care and lead to the development of a unified theory of mind.
마음의 오류들
세계적인 뇌과학자가 말하는, 우리 본성의 12가지 그림자 ★ 노벨생리의학상 수상자 ★ 올리버 색스, 하워드 가드너 추천 저자 ★ <뉴욕 타임스>, <허핑턴 포스트> 극찬 ★ 장동선 박사, 하지현 교수 강력 추천 노벨문학상을 수상하며 대중의 사랑을 한몸에 받은 어니스트 헤밍웨이나 윈스턴 처칠은 평생 지독한 우울증에 시달렸다. 반 고흐는 양극성장애를 앓던 그의 말년에 가장 뛰어난 작품을 그렸다. 영화 〈뷰티풀 마인드〉로 알려진 수학자 존 내시는 조현병 환자로서 엄청난 수학적 재능을 드러냈다. 도대체 어찌된 일일까? ...
The Importance Of Iron In Pathophysiologic Conditions
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protei...
Was ist der Mensch?
Was heißt es, Mensch zu sein? Nobelpreisträger Eric Kandel über die Grundlagen unserer Identität Was geschieht, wenn unser Gehirn nicht mehr »normal« funktioniert? Wenn es durch Störungen oder Krankheiten wie Alzheimer und posttraumatischen Stress in Unordnung geraten ist? Eric Kandel, einer der führenden Experten der Gehirn- und Gedächtnisforschung, hat sich mit der Frage beschäftigt, inwiefern komplexe menschliche Verhaltensweisen biologische Ursachen haben. In seinem Buch zeigt er, von Angstzuständen bis zur Schizophrenie, von Sucht bis Bipolarität, wie sehr biologische Prozesse unsere Identität prägen. Denn gerade die Störungen machen auf beeindruckende Weise sichtbar, was es heißt, Mensch zu sein.
La mente alterata
Il premio Nobel Eric Kandel ci porta alla scoperta di ciò che i disturbi cerebrali rivelano sulla natura umana. Lo studio della loro origine aiuta la ricerca di nuove terapie ma incoraggia anche un nuovo umanesimo, basato, almeno in parte, sulla conferma della natura biologica della nostra individualità. Kandel è uno dei pionieri delle moderne neuroscienze. Prendendo le mosse dalle sue ricerche, l’autore indaga una delle questioni fondamentali che dobbiamo affrontare: come nasce la nostra mente dalla materia fisica del cervello? Gli 86 miliardi di neuroni del cervello comunicano tra loro attraverso connessioni molto precise. Se queste connessioni sono interrotte o alterate, i processi cerebrali che danno origine alla nostra mente possono venirne disturbati, portando a malattie come la depressione, la schizofrenia e il morbo di Parkinson. «La mente alterata» illustra come i fondamentali studi di queste anomalie possano approfondire la nostra comprensione di pensiero, sentimento, comportamento, memoria e creatività, e forse portare, in futuro, alla formulazione di una teoria unificata della mente.
Drosophila
Written by respected researchers, it gives an excellent account of Drosophila as a model organism in molecular genetics and is suitable for postgraduate and postdoctoral researchers.
