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Unveiling the Tumor Microenvironment by Machine Learning to Develop New Immunotherapeutic Strategies (Volume I.B)
The tumor microenvironment (TME) plays a critical role in tumor proliferation, progression, and therapeutic responses. TME is a complex network of cancer cells, stromal cells, and, most importantly, infiltrating immune cells. Cancer cells regulate numerous biological functions through direct or indirect interaction with TME components. Emerging evidence suggests that TME crucially influences the response to both chemotherapy and immunotherapy. As scientific research has entered the big data era with the fast development of high-throughput sequencing technologies, machine learning has been gradually widely applied to extract important knowledge from big data bioinformatics. Thus, characterizing the TME landscape in cancer and identifying different immune-related TME phenotypes using machine learning-based bioinformatics analyses, in vitro experiments, and in vivo experiments are of great interest and significance.
Gastrointestinal Cancer Immunotherapy: from Drug Resistance Mechanisms to Overcoming Strategies
Gastrointestinal (GI) cancers, including gastric cancer, colon cancer, liver cancer, esophageal cancer, and pancreatic cancer, seriously threaten the health of human beings worldwide with a high rate of morbidity and mortality. The clinical successes achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 have opened a new cancer therapy era and brought new hope to cancer patients. However, the overall response rate (ORR) of ICI monotherapy in the non-selective population is only about 20%, in which some patients subsequently develop immunotherapy resistance. Moreover, the remaining 70-80% of patients displayed primary resistance to ICIs, and a few patients even exp...
Economic and Social Transformation in China
Now, for the first time, a set of influential research papers from the Center for China Studies have been put together in book form and in English, giving fascinating insights into Chinese economics and society.
China's Development Challenges
This book argues that a major potential source of social tension in transition and developing countries is not poverty as such, but vulnerability: that is, the risk of becoming poor. It demonstrates how in China many of the recent reforms to the public sector, such as decentralisation from central to local government, especially fiscal decentralisation; the reduction in public services provided by the state; the increasing practice of local government of charging fees for basic services which were previously free; de-collectivisation of the rural commune system and market sector experimentation in Economic Processing Zones have made many households extremely vulnerable to poverty. Having to ...
China's Three Decades of Economic Reforms
In the thirty years since China initiated economic reforms and its open-door policy, China has been transformed from a poor nation almost completely isolated from the global economy to an engine of growth of the world economy. China’s dynamic transition has been among the most dramatic developments of recent history; and its economy continues to grow rapidly, with important consequences for China’s own society and environment, as well as for the wider world. This book provides a fascinating insight into a wide range of issues on Chinese economy and its three decades of economic reforms. With well-researched, in-depth and comprehensive coverage of key topics, using the latest research findings, this book covers Chinese monetary policy and financial sector reforms; China’s income disparities; the emergence of China’s business groups; the implications of foreign direct investment and innovation and technological developments. The book will be an indispensable guide to scholars, entrepreneurs, policy-makers and all who are interested in China’s economic affairs.
Financial Sector Reform and the International Integration of China
China's economy, which continues to grow rapidly, is having an ever greater impact on the rest of the world. This impact is likely to be felt increasingly in the financial sector where China's foreign currency reserves, fuelled by the huge trade surplus, are a very significant factor in world financial markets. This book, based on extensive original research by a range of leading experts, examines many key aspects of current reforms in China's financial sector and China's increasing integration into the international economy. Subjects covered amongst many others include: the derivatives market in China; stock market liberalisation; the internationalization of accounting standards in China; the impact of international foreign direct investment by Chinese firms; and a discussion of the likely long-term economic effects of the Beijing Olympic Games.
Whither China's Democracy? Democratization in China Since the Tiananmen Incident
This weighty monograph offers a thoughtful assessment of one of globally raising China’s most profound political issues—democratization since the 1989 Tiananmen Incident. Not exactly a “looking back” retrospective nor a typical commemorative work, this book harbors a more forward prospecting approach with 13 substantive chapters yielding informed analysis and insightful interpretations of various key issues. The core subjects range from legal foundation of Chinese democracy, middle-class politics, Internet based-democratization debates and pro-democratic mobilizations, civic society activism, to the external and international media’s inputs, democracy and China’s ethnic minorities; and PRC-Vatican interface. Published by City University of Hong Kong Press. 香港城市大學出版社出版。
