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The progression from normal glucose tolerance (NGT) to type 2 diabetes involves intermediate stages of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), also known as prediabetes. The pathophysiology underlying the development of these glucose metabolic alterations is multifactorial, leading to an alteration in the balance between insulin sensitivity and insulin secretion. Our knowledge of the molecular basis of the signaling pathways mediating the various physiologic effects of insulin is steadily advancing. New substrates and signaling molecules have been identified and potential mechanisms involved in the pathophysiology of type 2 diabetes have been revealed. This book summarises the current state of knowledge on the pathophysiology underlying the progression from normal glucose tolerance to type 2 diabetes and therapeutic advances in the improvement of glycaemic control in prediabetic and diabetic states.
An estimated 50 million Americans suffer from some form of autoimmune disease. If you're among them, you may know all too well how little modern medicine can do to alleviate your condition. But that's no reason to give up hope. In this groundbreaking book, Sarah D. Ballantyne, PhD, draws upon current medical research and her own battle with an autoimmune disorder to show you how you can become completely symptom-free—the natural way. The Paleo Approach is the first book ever to explain how to adapt the Paleo diet and lifestyle to bring about a full recovery. Read it to learn why foods marketed as "healthy"—such as whole grains, soy, and low-fat dairy—can contribute to the development o...
Metoda Paleo este prima carte care explică modul în care această abordare poate favoriza o recuperare deplină în urma bolilor autoimune. Citind această carte puteţi afla ce anume să mâncaţi pentru a vă putea întări sistemul imunitar, reduce bolile inflamatorii şi a vă ajuta corpul să se vindece. Veţi descoperi modul în care anumite schimbări simple în stilul de viaţă – împreună cu schimbările regimului alimentar – vor avea ca efect îmbunătăţirea considerabilă a stării voastre de sănătate. Veţi putea înţelege de ce alimentele considerate „sănătoase“ – cum ar fi cerealele integrale, boabele de soia şi produsele lactate cu conţinut scăzut de gr...
Routledge English Language Introductions cover core areas of language study and are one-stop resources for students. Assuming no prior knowledge, books in the series offer an accessible overview of the subject, with activities, study questions, sample analyses, commentaries and key readings—all in the same volume. The innovative and flexible ‘two-dimensional’ structure is built around four sections—introduction, development, exploration and extension—which offer self-contained stages for study. Each topic can also be read across these sections, enabling the reader to build gradually on the knowledge gained. Revised and updated throughout, this third edition of Practical Phonetics a...
Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.
Praise for this book:[Four stars] At once a textbook, a surgical atlas, and a source of current practice guidelines...This is a high-quality, thorough and insightful resource that provides accessible and essential information...recommend[ed].--Doody's ReviewThyroid and Parathyroid Diseases: Medical and Surgical Management is a state-of-the-art reference for optimizing the care of patients with thyroid and parathyroid diseases. The book opens with a thorough discussion of anatomy, physiology, and imaging of the thyroid. The chapters that follow are divided into three main sections that cover the medical and surgical treatments for benign thyroid diseases, thyroid malignancy, and parathyroid d...
This book covers a selected number of hot topics in endocrine and hormone-related pathologies, discussed by eminent scientists and clinicians coming from different countries of the world. It deals with advanced recent trends in the field, including neuroendocrine and pituitary tumors, thyroid dysfunctions, diabetes and a series of endocrine-related diseases, such as those related to the anabolic effects of testosterone, obesity, cancer, the liver complications of diabetes and the pediatric nonalcoholic fatty liver disease. The readers should be able to have a basic, as well as critic and advanced, overview of these selected hot pathologies of the endocrine system.
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In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors ...