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Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
How hormonal signals in one small structure of the brain—the hypothalamus—govern our physiology and behavior. As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small structure of the neuroendocrine brain—the hypothalamus—influences what we do, how we love, and who we are. The hypothalamus contains a large variety of neurons. These communicate not only through neurotransmitters, but also through peptide signals that act as hormones within the brain. While neurotransmitter signals tend to be ephemeral and confined by anatomical connectivity, the hormone signals that hypothalamic neurons generate are potent, wide-reaching, and long-lasting. Leng explores the evolutionary origins of these remarkable neurons, and where the receptors for their hormone signals are found in the brain. By asking how the hypothalamic neurons and their receptors are regulated, he explores how the hypothalamus links our passions with our reason. The Heart of the Brain shows in an accessible way how this very small structure is very much at the heart of what makes us human.
Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.
Physiologists, Biomedical Scientists and Clinicians: Bridging the Intellectual and Communication Gap with the Public and Decisionmakers, the latest release in the Fundamentals of Physiology series, provides valuable information to inform researchers and clinicians and better train students on the broader aspects of the scientific process and how to best counteract mis- and disinformation. This book is published in concert with the International Union of Physiological Sciences and is a useful resource for lecturers when training physiologists, biomedical scientists, medical and allied health students. Faculty, students, researchers, and clinicians are struggling how to deal with the post-trut...
The statistics are alarming. Some say that once every nine minutes a woman in the United States is beaten by her spouse or partner. Others claim that once every four minutes a woman in the world is beaten by her spouse or partner. More women go to emergency rooms in the United States for injuries sustained at the hands of their spouses and partners than for all other injuries combined. Shelters for battered women are filled beyond capacity every single day of the year. Despite the overwhelming evidence that violence in our homes is a daily reality, most of us are not willing to acknowledge this private violence or talk about it openly. Women Escaping Violence brings women's stories to the at...
Brings together the Perspectives and Topical Reviews published during 1998 in The Journal of Physiology.
The GnRH Neuron and its Control examines the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult GnRH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of GnRH release. The book also reviews the neurobiolog...
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Using a multidisciplinary approach, it combines anatomical, cellular and physiological studies by preeminent experts. Features important insights into the function of the hypothalamus.
This book combines technology and the medical domain. It covers advances in computer vision (CV) and machine learning (ML) that facilitate automation in diagnostics and therapeutic and preventive health care. The special focus on eXplainable Artificial Intelligence (XAI) uncovers the black box of ML and bridges the semantic gap between the technologists and the medical fraternity. Explainable AI in Healthcare: Unboxing Machine Learning for Biomedicine intends to be a premier reference for practitioners, researchers, and students at basic, intermediary levels and expert levels in computer science, electronics and communications, information technology, instrumentation and control, and electri...