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This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action. This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial phys...
Targeting the key active elements in the mechanism and application of apoptosis and its therapeutic implications, Apoptosis: Modern Insights into Disease from Molecules to Man covers apoptosis from A to Z. Comprehensive in scope, it explores a wide range of topics including various cancers, asthma, and multiple sclerosis as well as alcohol induced
La fuerza del amor paternal, moverá todas las piezas del tablero para dar regreso a un sentimiento jamás sentido y a la debilitada mente maternal que sí lo experimentó. De la mano de su inseparable progenitor, deberán sortear obstáculos, con la inminente exposición de altas emociones. Manteniendo la fe, la esperanza y la sabiduría de la mente y del corazón, con la única prioridad de devolver el tesoro perdido a un atormentado corazón maternal. Aunque quizás, no sea como lo soñado, pero siempre habra una manera de ver las cosas que los haga sentir que han encontrado la felicidad, aún así, cuando ésta no sea completa.
Is the spirit a mysterious internal force or a religious ideal? Is it a tangible reality or a magical construct? This text attempts to answer these questions by proposing a new interpretation of the work of modern and contemporary European artists.
“Evidencias. Las otras dramaturgias” tiene por objetivo ser un documento que posicione la voz dramática de mujeres del siglo XX, visibilizando su creación y aportando a la escena teatral chilena y latinoamericana desde su variedad temática y estilística, reflejado en la diversidad de mundos e imaginarios que habitan los personajes al interior de las obras, pero también, a la construcción de una genealogía del quehacer de las mujeres desde una perspectiva de género. La presente antología busca mermar el sesgo en materia dramática a partir de la selección de doce obras que componen este primer tomo, invitándonos a revisitar otros contextos al indagar en las historias, personaje...