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Computer Aided Verification
This book constitutes the refereed proceedings of the 24th International Conference on Computer Aided Verification, CAV 2012, held in Berkeley, CA, USA in July 2012. The 38 regular and 20 tool papers presented were carefully reviewed and selected from 185 submissions. The papers are organized in topical sections on automata and synthesis, inductive inference and termination, abstraction, concurrency and software verification, biology and probabilistic systems, embedded and control systems, SAT/SMT solving and SMT-based verification, timed and hybrid systems, hardware verification, security, verification and synthesis, and tool demonstration.
Immunity and Immunopathogenesis to Herpesviruses
Herpesviruses are a large group of double-stranded DNA viruses, which have evolved strategies to persist and disseminate widely throughout the human population. Unlike RNA viruses which have the ability to alter their antigenic expression profile to evade host immune responses, herpesviruses can establish life-long latency in the infected host. Herpesviruses are divided into alpha, beta and gamma herpesviruses sub-families. The human members of the alpha-herpesvirinae subfamily is comprised of herpes simplex virus-1 and 2 (HSV-1 and HSV-2) and of varicella-zoster virus (VZV). These viruses are considered neurotropic, as they can (i) infect nerve endings; (ii) traffic via neuronal axons and (...
The Science and Regulations of Naturally Derived Complex Drugs
This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design considerations, and the regulatory science applications to development of such complex mixtures. Complex mixtures are challenging to characterize and analyze using standard methods. Further challenges extend thro...
Augmented Reality and Virtual Reality
This book presents a collection of the latest research in the area of immersive technologies, presented at the International Augmented and Virtual Reality Conference 2018 in Manchester, UK, and showcases how augmented reality (AR) and virtual reality (VR) are transforming the business landscape. Innovations in this field are seen as providing opportunities for businesses to offer their customers unique services and experiences. The papers gathered here advance the state of the art in AR/VR technologies and their applications in various industries such as healthcare, tourism, hospitality, events, fashion, entertainment, retail, education and gaming. The volume collects contributions by prominent computer and social sciences experts from around the globe. Addressing the most significant topics in the field of augmented and virtual reality and sharing the latest findings, it will be of interest to academics and practitioners alike.
Global Dynamics in Travel, Tourism, and Hospitality
Worldwide, tourism is the third largest economic activity in direct earnings after petroleum and automobile industries, and by far the largest one if indirect earnings are also taken into consideration. Taking into account the profound economic impact the tourism and hospitality industries can have on regions and cities around the world, further research in this area is critical. Global Dynamics in Travel, Tourism, and Hospitality takes a holistic approach to tourism and hospitality operations, education, and research. Highlighting the latest research in the field, real-world examples of how these industries are shaping economic development as well as future outlooks and opportunities for growth, this publication is an essential reference source for researchers, professionals, and graduate-level students.
Plant and Human Health, Volume 1
Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quali...
The Garbage Collection Handbook
Universally acclaimed as the book on garbage collection. A complete and up-to-date revision of the 2012 Garbage Collection Handbook. Thorough coverage of parallel, concurrent and real-time garbage collection algortithms including C4, Garbage First, LXR, Shenandoah, Transactional Sapphire and ZGC, and garbage collection on the GPU. Clear explanation of the trickier aspects of garbage collection, including the interface to the run-time system, handling of finalisation and weak references, and support for dynamic languages. New chapters on energy aware garbage collection, and persistence and garbage collection. The e-book includes more than 40,000 hyperlinks to algorithms, figures, glossary entries, indexed items, original research papers and much more. Backed by a comprehensive online database of over 3,400 garbage collection-related publications
Retinal Development
This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.
Theorem Proving in Higher Order Logics
This volume constitutes the proceedings of the 22nd International Conference on Theorem Proving in Higher Order Logics (TPHOLs 2009), which was held during August 17-20, 2009 in Munich, Germany. TPHOLs covers all aspects of theorem proving in higher order logics as well as related topics in theorem proving and veri?cation. There were 55 papers submitted to TPHOLs 2009 in the full research c- egory, each of which was refereed by at least three reviewers selected by the ProgramCommittee. Of these submissions, 26 researchpapers and 1 proofpearl were accepted for presentation at the conference and publication in this v- ume. In keeping with longstanding tradition, TPHOLs 2009 also o?ered a venue...
PROCEEDINGS OF THE 21ST CONFERENCE ON FORMAL METHODS IN COMPUTER-AIDED DESIGN – FMCAD 2021
Our life is dominated by hardware: a USB stick, the processor in our laptops or the SIM card in our smart phone. But who or what makes sure that these systems work stably, safely and securely from the word go? The computer - with a little help from humans. The overall name for this is CAD (computer-aided design), and it’s become hard to imagine our modern industrial world without it. So how can we be sure that the hardware and computer systems we use are reliable? By using formal methods: these are techniques and tools to calculate whether a system description is in itself consistent or whether requirements have been developed and implemented correctly. Or to put it another way: they can b...
