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Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
Handbook of Research on Essential Information Approaches to Aiding Global Health in the One Health Context
Post COVID-19 pandemic, researchers have been evaluating the healthcare system for improvements that can be made. Understanding global healthcare systems’ operations is essential to preventative measures to be taken for the next global health crisis. A key part to bettering healthcare is the implementation of information management and One Health. The Handbook of Research on Essential Information Approaches to Aiding Global Health in the One Health Context evaluates the concepts in global health and the application of essential information management in healthcare organizational strategic contexts. This text promotes understanding in how evaluation health and information management are decisive for health planning, management, and implementation of the One Health concept. Covering topics like development partnerships, global health, and the nature of pandemics, this text is essential for health administrators, policymakers, government officials, public health officials, information systems experts, data scientists, analysts, health information science and global health scholars, researchers, practitioners, doctors, students, and academicians.
Food Science and Technology
This brand new comprehensive text and reference book is designed to cover all the essential elements of food science and technology, including all core aspects of major food science and technology degree programs being taught worldwide. Food Science and Technology, supported by the International Union of Food Science and Technology comprises 21 chapters, carefully written in a user-friendly style by 30 eminent industry experts, teachers and researchers from across the world. All authors are recognised experts in their respective fields, and together represent some of the world’s leading universities and international food science and technology organisations. Expertly drawn together, produ...
Successful Technology Licensing
This Successful Technology Licensing (STL) Manual was developed as a response to requests for a user-friendly manual aimed primarily at an audience of businesspersons, technology managers and scientists who are dealing with licensing in the course of their work. Licensing occurs in the context of various business and collaboration relations, such as mergers and acquisitions, joint ventures, research collaboration agreements, joint research and development arrangements, etc.
Proceedings of IDEAS 2019
This book presents the proceedings of the IDEAS Conference, which is intended as a forum for a new generation of researchers. IDEAS is an arena that encourages researchers to defy their field's boundaries, leveraging disciplinary mindset into contributions to broad domains within the Science, Technology, Engineering, Entrepreneurship, and Management. Further, IDEAS explores novel questions and challenges existing policies and practices on how to apply science and technology as an input to design more innovative and sustainable systems that promote human well-being.
The Maias
In this simple tale, the novel's hero is the talented heir to a notable family in Lisbon. He aspires to serve his fellow man in his chosen profession of medicine, in the arts, and in politics. But he enters a society affected by powerful international influences--French intellectual developments, English trading practices--that trouble and frustrate him. In the end he is reduced to a kind of spiritual helplessness and his good intentions are reduced to dilettantism. His passionate love affair begins to suffer a devastating constraint.
