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Interdisciplinary management of central nervous system metastasis and neoplastic meningitis: recent developments and future perspectives
The incidence of metastatic disease in the central nervous system (CNS) is rising. According to current estimates, up to a third of adult cancer patients will suffer from CNS metastasis. Clinical evidence-based data from prospective randomized trials are rare, however, because CNS metastasis patients were often excluded from clinical trial participation. The management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary challenge. Recent basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the CNS. This report reviews advances, challenges, and perspectives in this field.
Modern Proteomics – Sample Preparation, Analysis and Practical Applications
This volume serves as a proteomics reference manual, describing experimental design and execution. The book also shows a large number of examples as to what can be achieved using proteomics techniques. As a relatively young area of scientific research, the breadth and depth of the current state of the art in proteomics might not be obvious to all potential users. There are various books and review articles that cover certain aspects of proteomics but they often lack technical details. Subject specific literature also lacks the broad overviews that are needed to design an experiment in which all steps are compatible and coherent. The objective of this book was to create a proteomics manual to...
Data Integration in the Life Sciences
This book constitutes revised selected papers from the 13th International Conference on Data Integration in the Life Sciences, DILS 2018, held in Hannover, Germany, in November 2018. The 5 full, 8 short, 3 poster and 4 demo papers presented in this volume were carefully reviewed and selected from 22 submissions. The papers are organized in topical sections named: big biomedical data integration and management; data exploration in the life sciences; biomedical data analytics; and big biomedical applications.
Machine Learning on Commodity Tiny Devices
This book aims at the tiny machine learning (TinyML) software and hardware synergy for edge intelligence applications. It presents on-device learning techniques covering model-level neural network design, algorithm-level training optimization, and hardware-level instruction acceleration. Analyzing the limitations of conventional in-cloud computing would reveal that on-device learning is a promising research direction to meet the requirements of edge intelligence applications. As to the cutting-edge research of TinyML, implementing a high-efficiency learning framework and enabling system-level acceleration is one of the most fundamental issues. This book presents a comprehensive discussion of...
Systems Medicine
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling...
Introduction to Proteomics
Introduction to Proteomics is written by seasoned researchers with years of practical experience. In addition to comprehensive discussions of the basic concepts, techniques, and applications of the subject, the text also includes an extensive glossary and a chapter containing laboratory exercises and protocols. While mass spectrometry is central to proteomics, the book discusses all of the analytical techniques a student is likely to need when faced with real-world problems, such as sample preparation, chromatographic and electrophoretic separation, micro-total analysis systems, and bioinformatics.
Kommunikation und Kontrolle
Kaum ein anderer Zeitraum der europäischen Geschichte des 20. Jahrhunderts hat so viele Gerüchte hervorgebracht wie die ersten Wochen des Ersten Weltkrieges. Gerüchte sind mehr als nur amüsante Anekdoten einer aufgeregten Zeit. Als Massenerscheinung verweisen sie auf komplexe Veränderungen im Verhältnis zwischen Staat, Publikum und "öffentlicher Meinung." Der Erste Weltkrieg war auch ein Medienkrieg, der sowohl in Großbritannien als auch im Deutschen Reich zu Glaubwürdigkeitskrisen der Presse führte. Als Folge entstanden und verbreiteten sich Gerüchte als ein komplementäres Element öffentlicher Kommunikation. Florian Altenhöner legt dar, wie Gerüchte einen kommunikativen Raum des Möglichen konstruierten, in dem sich Wünsche, Ängste und Erwartungshaltungen entfalten konnten.
Advanced Healthcare Materials
Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called therano...
