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Genetic Polymorphism and cancer susceptibility
This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
Genetic Polymorphism and Disease
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases espe...
Cancer Care in Areas of Conflict
Cancer is a global burden with more than 18 million diagnosed and an estimate of 10 million deaths in 2020 worldwide. Cancer continues to be a major and growing problem in conflict affected areas too. The incidence of cancer is expected to rise significantly in those countries compared to the rest of the world. Conflict, massive migration and displacement has put a tremendous pressure on all health care systems and health economy which halted improvement in many cancer care in majority of the countries. Countries affected by conflict like Syria, Ukraine, Iraq, Yemen, Latin America and others has led to destruction of the whole countries healthcare infrastructure including health care facilit...
Therapeutic Applications of Honey and its Phytochemicals
Honey typically has a complex chemical and biochemical composition that invariably includes complex sugars, specific proteins, amino acids, phenols, vitamins, and rare minerals. It is reported to be beneficial in the treatment of various diseases, such as those affecting the respiratory, cardiovascular, gastrointestinal, and nervous systems, as well as diabetes mellitus and certain types of cancers; however, there is limited literature describing the use of honey in modern medicine. This book provides evidence-based information on the pharmaceutical potential of honey along with its therapeutic applications and precise mechanisms of action. It discusses in detail the phytochemistry and pharmacological properties of honey, highlighting the economic and culturally significant medicinal uses of honey and comprehensively reviewing the scientific research on the traditional uses, chemical composition, scientific validation, and general pharmacognostical characteristics. Given its scope, it is a valuable tool for researchers and scientists interested in drug discovery and the chemistry and pharmacology of honey.
Fig (Ficus carica): Production, Processing, and Properties
This book creates a multidisciplinary forum of discussion on Ficus carica with particular emphasis on its horticulture, post-harvest, marketability, phytochemistry, extraction protocols, biochemistry, nutritional value, functionality, health-promoting properties, ethnomedicinal applications, technology and processing. The impact of traditional and innovative processing on the recovery of high-added value compounds from Ficus carica byproducts is extensively reported. Also, the text discusses the potential applications of Ficus carica in food, cosmetics, and pharmaceutical products. Fig (Ficus carica): Production, Processing, and Properties illustrates a diversity of developments in food scie...
Cancer Epidemiology in China: What We Have Learnt So Far?
After several decades of development, the socialist market economy of China is now the world’s second largest economy by nominal GDP. China is also the largest economy by purchasing power parity according to the International Monetary Fund. In tandem with the development of the Chinese economy, China’s cancer burden is rising rapidly due to an ageing population and the adoption of unhealthy lifestyle behaviours. According to the data from the National Central Cancer Registry (NCCR) of China, the incidence and mortality of cancer have been increasing rapidly in China. In recent years, cancer has been the leading cause of death among city residents and the second cause of death among rural...
EBV-Associated Carcinomas: Presence, Role and Prevention Strategies
This Research Topic aspires to provide a platform for research papers, reviews, perspectives and thought-provoking opinions and ideas about EBV infection and its role in human carcinomas as well as prevention using upcoming vaccine. This should pave the way to translate findings into cost effective strategies to eliminate EBV infection and its related cancers worldwide.
New Treatment Modalities in Rectal Cancer
This book provides an up-to-date and detailed overview of diagnostic and management strategies for rectal cancer. It includes chapters focusing on recent diagnostic modalities such as technical advances, the role of magnetic resonance imaging (MRI), immunology, and histopathology, as well as the latest surgical techniques for the management of rectal cancer. It also discusses the role of adjuvant, neo-adjuvant and non-operative approaches. Further, it presents the recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, clearly and concisely, linking each topic to the therapeutic options arising from the staging. A large part of this multifaceted book is devoted to the in-hospital care of rectal cancer patients, from the fast-track procedures and enhanced recovery systems to detailed descriptions of the available surgical techniques, including salvage situations, accidents, complications and their treatment.
Phytomedicine
Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequen...
