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Misadventures is a unique ensemble of mishaps and anecdotes revealing the ups and downs of one woman's life in twentieth-century London. Sylvia Smith's deadpan patter belies the startling complexities, humour and darkness at the heart of this remarkable memoir.
Sylvia chooses between two dates for the prom, daydreams, dresses for a Halloween party, remembers a Thanksgiving from the past, and tries to cope with her parents' divorce.
"Seven months after the death of my father, my half-brother Renzo, then twenty-six-years old, delivered me to the nuns at the convent in Tripoli. I remember Renzo crying, but I can't remember my reaction to this life-changing event. Although I was leaving my home, my mother, my baby brother, and all that I called my life, the feelings of that day are gone. Perhaps after my father's death, I ceased trying to feel anything." As World War II encroaches upon North Africa, Mussolini dictates that the children from this Italian colony be sent to Italy for their protection. The anticipated four-month "vacation" in Italy in the hands of the Franciscan nuns starts in June of 1940 and lasts seven year...
Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system. Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating questions, which can be addressed experimentally using today’s technology. This book will be a valuable resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model systems and underscores the importance of their study to further understand their complex, and often enigmatic, biology.
Appleby House is Sylvia Smith’s delightful, refreshingly candid account of a year spent in a shabby bed-sit in 1980s London’s East End. Smith’s engrossing, understated narrative invests the story of shared living: shifting allegiances, cleaning negotiations, debates about whose turn it is to change the toilet paper (it’s color-coded) and who’s been stealing whose hot water (50p buys 2 baths) with compulsive suspense of the highest order. As tensions build around Laura’s adamant refusal to turn down her music or pretend to care about what her housemates have to say, we find ourselves astonishingly addicted to the goings on in this tiny corner of the universe. In the most artless and amusing way, Appleby House thoroughly indulges our very human fascination with the day-to-day and the surprising, often inexplicable, behavior of our fellow members of the species.
Sylvia Plath (1932-1963) was one of the writers that defined the course of twentieth-century poetry. Her vivid, daring and complex poetry continues to captivate new generations of readers and writers. In the Letters, we discover the art of Plath's correspondence. Most has never before been published, and it is here presented unabridged, without revision, so that she speaks directly in her own words. Refreshingly candid and offering intimate details of her personal life, Plath is playful, too, entertaining a wide range of addressees, including family, friends and professional contacts, with inimitable wit and verve. The letters document Plath's extraordinary literary development: the genesis ...
THE EAST VILLAGE, NYC, 1976. A 26-year-old starving poet needs $60. What else to do but register with a temp agency as a house cleaner? The excitement never wanes as he is catapulted into the everyday yet unimaginable worlds behind closed (apartment) doors. Bob knows one thing: the dirt will always win. Clients are a bit more unpredictable, he discovers, as he comes to terms with eccentric domestic habits and strange discoveries. When Bob becomes a weekly fixture in his clients’ lives, anything can happen, and does, including a memorable encounter with an obliging Hoover that ultimately proves unable to get the job done. Cleaning Up New York has been a cult classic since it was first published in 1976 in an edition of 750.
Sylvia is a heroine loved by two men of completely different types. The novel follows her development from a wilful, imaginative, but not especially clever girl, to an alert woman who has been matured by her suffering.
Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
The electrifying diaries that are essential reading for anyone moved and fascinated by the life and work of one of America's most acclaimed poets. Sylvia Plath began keeping a diary as a young child. By the time she was at Smith College, when this book begins, she had settled into a nearly daily routine with her journal, which was also a sourcebook for her writing. Plath once called her journal her “Sargasso,” her repository of imagination, “a litany of dreams, directives, and imperatives,” and in fact these pages contain the germs of most of her work. Plath’s ambitions as a writer were urgent and ultimately all-consuming, requiring of her a heat, a fantastic chaos, even a violence that burned straight through her. The intensity of this struggle is rendered in her journal with an unsparing clarity, revealing both the frequent desperation of her situation and the bravery with which she faced down her demons.