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Oncogenes as Transcriptional Regulators
The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and t...
Brandenburg
Glenn Meade, the acclaimed, bestselling author of The Second Messiah, delivers unrivaled suspense, unforgettable characters, and a brilliantly absorbing story as a British agent and a German woman find themselves unraveling a plot to bring about the Fourth Reich. A secret that must never be revealed. . . . An evil never meant to be repeated. . . . Seventy years ago, the greatest crime against humanity was committed. Today it’s only a heartbeat away from happening again. In Paraguay, an elderly businessman kills himself. In Berlin, a neo-Nazi is gunned down in the street. Trying to connect the murders, intelligence agent Joe Volkmann, aided by a beautiful young German journalist, travels to...
Macrocyclic and Supramolecular Chemistry
This book commemorates the 25th anniversary of the International Izatt-Christensen Award in Macrocyclic and Supramolecular Chemistry. The award, one of the most prestigious of small awards in chemistry, recognizes excellence in the developing field of macrocyclic and supramolecular chemistry Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field features chapters written by the award recipients who provide unique perspectives on the spectacular growth in these expanding and vibrant fields of chemistry over the past half century, and on the role of these awardees in shaping this growth. During this time there has been an upsurge of interest in the desig...
Animal Virology V4
Animal Virology consists of papers presented in a meeting which considered broad issues and advances in animal virology and tumor viruses. This book is divided into nine parts, representing the nine sessions of the meeting. Five of the nine sections deal particularly with viruses known to be oncogenic in animals, and one of these covers explicitly human oncornaviruses. The other four sections describe the processes common to all viruses: replication, protein synthesis, and persistence, wherein emphasis is given to negative strand viruses and plant viruses.
Maori Folk-tales of the Port Hills, Canterbury, New Zealand
With the opening of tracks along the bold range of heights between the Canterbury Plains and Lyttelton Harbour, and the acquisition of new reserves for the public, mainly through the efforts of one tireless worker, Mr. H. G. Ell, Christchurch residents are perhaps coming to a more lively sense of the value of the Port Hills as a place of genuine recreation. The Summit Road has made city people free of the grandest hilltop pleasure place that any New Zealand city possesses within easy distance of its streets, and the worth of this mountain track, so easily accessible and commanding so noble a look-out over sea and plains and Alps, will increase in proportion to the growth of the Christchurch ...
Leukemia
and how the known vertebrate homologues of these genes are expressed normally in differentiation and proliferation pathways as well as abnormal ly in well-defined lymphomagenic and other oncogenic pathways. What emerged from this meeting are a better understanding of the evolution of these gene systems themselves and an elucidation of simpler systems open to more rapid genetic and molecular genetic analysis to reveal the normal functions of these genes and their gene products. Thus we sought new answers to several old questions concerning differenti ation, proliferation, and neoplastic transformation. We gathered together in an unusual format - that of the unique Dahlem Workshops - not just to reiterate data which has recently emerged but to think about how these findings might lead to new approaches for the understanding and therapy of the leukemias and lymphomas. We deliberately chose experts from several different disciplines, ranging from the clinicians who diag nose, describe, and treat these maladies, to the molecular geneticists trying to reduce the analysis of the problem to its simplest variables in the simplest systems possible.
Climatological Data for the United States by Sections
Collection of the monthly climatological reports of the United States by state or region, with monthly and annual national summaries.
