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This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapter...
This book focuses on the latest progress in chemotherapy for leukemia and related diseases, including still-ongoing but promising studies. The effectiveness of treatment for chronic myeloid leukemia and acute promyelocytic leukemia has been dramatically improved in recent years. This improvement has been made possible with the development of molecular targeted agents such as bcr-abl tyrosine kinase inhibitors and all-trans retinoic acid. The antibody for the unique target of chemokine receptor 4 for adult T-cell leukemia/lymphoma, or FLT3 inhibitors (signaling inhibitors) has been applied to other leukemias. Also, chemotherapeutic agents including antimetabolite analogues such as clofarabine...
This book presents papers from the International Conference on Sustainable Civil Engineering and Architecture 2019, which was held in Ho Chi Minh City, Vietnam, from 24–26 October 2019. The conference brought together international experts from both academia and industry to share their knowledge and experiences, and to facilitate collaboration and improve cooperation in the field. The book highlights the latest advances in sustainable architecture and civil engineering, covering topics such as offshore structures, structural engineering, construction materials, and architecture.
The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults...
The book starts with basic overview of physical phenomena on laser-matter interaction. Then it is followed by presentation of a number of laser applications in the nano-particles and thin films production, materials examination for industry, biological applications (in-vitro fertilization,tissue ablation) and long-range detection issues by LIDARs.
Non-Destructive Testing and Condition Monitoring Techniques in Wind Energy looks at the complex and critical components of energy assets and the importance of inspection and maintenance to ensure their high availability and uninterrupted operation. Presenting the main concepts, state-of-the-art advances and case studies, this book approaches the topic by considering it as an integral part of the overall operation of any wind energy project. Linking the essential NDT subject with its sub disciplines, the book uses computational techniques, dynamic analysis, probabilistic methods, and mathematical optimization techniques to support analysis of prognostic problems with defined constraints and r...
With their similarity to the organs of the most advanced creatures that inhabit the Earth, sensors are regarded as being the “senses of electronics”: arti?cial eyes and ears that are capable of seeing and hearing beyond the range of - man perception; electronic noses and tongues that can recognise odours and ?avours without a lifetime training; touch that is able not only to feel the texture and temperature of the materials but even to discern their chemical compo- tion. Among the world of chemical sensors, optical devices (sometimes termed “optodes”, from the Greek “the optical way”) have reached a prominent place in those areas where the features of light and of the light-matte...
This book surveys key projects that have seen the construction of large floating structures or have attained detailed conceptual designs. This compilation of key floating structures in a single volume captures the innovative features that mark the technological advances made in this field of engineering and will provide a useful reference for ideas, analysis, design and construction of these unique and emerging urban projects to offshore and marine engineers, urban planners, architects and students.
Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer – From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.