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Novel biomarkers in tumor immunity and immunotherapy
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there...
T Cell Protocols
The purpose of T Cell Protocols: Development and Activation is to c- lect a series of protocols, particularly those that have been developed within the past few years, to help investigators master new techniques (or improve existing ones) for the study of T-cell Biology. Invariably, in putting together a book like this it is difficult to decide which methods to include and which to leave out. To this end methods were selected from a variety of disciplines, including cellular immunology, b- chemistry, and molecular biology, to try to provide something of interest for everyone who works on T-cell development and activation. I would like to mention that my primary reason for agreeing to put thi...
塩野義硏究所年報
Vols. for 1975- contain the summaries of the staff publications.
Recent Advances in Precision Vaccine Discovery & Development
Topic Editor Jay Evans is the co-founder, President and CEO of Inimmune Corporation. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Earthquake Geotechnical Case Histories for Performance-Based Design
Earthquake Geotechnical Case Histories for Performance-Based Design is a collection of 26 case histories, each study containing well-instrumented geotechnical and earthquake data. The book is intended to serve as a reference work, since it contains a common scale to develop and implement design methodologies and numerical analyses, so that their reliability can be evaluated. Each case history consists of site characterization, earthquake motions and descriptions of failure as quantitative as possible. Wherever available, digital data on earthquake records and other information associated with individual cases are supplied in the attached CD-ROM as text files EARTHQUAKE GEOTECHNICAL CASE HISTORIES FOR PERFORMANCE-BASED DESIGN will be invaluable to researchers in earthquake geotechnical engineering, practicing geotechnical engineers, as well as engineers and researchers interested in numerical analysis.
