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From GWAS Hits to Treatment Targets
Genome-wide association (GWA) studies, as a prototype of large-scale OMICs studies, have advanced our understanding of the genetic basis of many common diseases. With respect to coronary artery disease (CAD) and cardiovascular risk factors, like lipids, blood pressure or BMI, they have identified hundreds of chromosomal loci that modulate disease risk. Despite their scientific success, GWA studies have been criticized for having failed so far in delivering diagnostically or therapeutically relevant products. However, the ability to achieve such goals has been strengthened recently by further layers of OMICs-based data, including large-scale transcriptomics data, and better annotation of regu...
A Statistical Approach to Genetic Epidemiology
A Statistical Approach to Genetic Epidemiology After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-Süssmilch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on “Model Free Linkage Analysis of Quantitative Traits” in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery.
Endocrine Abnormalities and Renal Complications
Vertebrate kidneys play a vital role in regulating body homeostasis, in addition to being instrumental in preventing large blood molecules from filtering out into the urine. Several endocrine factors have an influential role in renal health. Hormones are necessary for the normal health of the kidney and altered levels of them are harmful to glomerular health, manifesting in chronic kidney disease and proteinuria. Recent evidence attributes novel roles to several endocrine mediators in renal biology, including growth hormone, thyroxine, and glucocorticoids. In recent times, researchers have demonstrated altered levels of these hormones elicit a decline in renal function by afflicting several cellular and molecular manifestations in specific renal cells. More research is needed to better understand this connection and its potential translational implications.
Genetic Causes of Cardiac Disease
This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives. The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists.
Chronic Coronary Artery Disease: A Companion to Braunwald's Heart Disease E-Book
Featuring expert guidance from Drs. James de Lemos and Torbjørn Omland, as well as other globally known leaders in cardiology, Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary syndromes. This brand-new companion to Braunwald's Heart Disease was designed as a stand-alone reference for physicians treating patients who present with complex, unique challenges, offering the latest information on the use of imaging modalities in diagnosis and treatment, advances in interventional and surgical approaches to revascularization, new medications to improve symptoms and outcomes in chronic CAD, and much more. - Covers every aspect of ...
AHA Scientific Sessions 2016: Program Information
The American Heart Association’s Scientific Sessions 2016 is bringing big science, big technology, and big networking opportunities to New Orleans, Louisiana this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
The Lancet: Cardiovascular Disease 2012
This book, featuring content from the Aug 11, 2012, issue of The Lancet, has been released to coincide with the European Society of Cardiology (ESC) meeting in Munich, Germany, which is to be held on Aug 25–29, 2012. The Lancet is strongly supportive of cardiology as can be seen from the substantial relevant content in this compilation. In 2011, The Lancet published more papers in this specialty than any other: cardiovascular research contributed about one in four of all published research papers. Featured within are three research articles on lipids and cardiovascular disease which provide balance on the role of high density lipoproteins in cardiovascular disease, and on statins in preven...
Respekt!
Anlässlich des 100. Jubiläums der Universität Hamburg widmet sich der umfangreich Sammelband der Geschichte von Frauen und der Frauen- und Geschlechterforschung an der Universität Hamburg: Von den ersten Wissenschaftlerinnen und Studentinnen, über das erste Frauenseminar bis zu den heutigen Forschungsprojekten und Institutionen. Die Originaldokumente (Flugblätter, Plakate, Notizen, Briefe etc.), Interviews und Beiträge spiegeln die Rahmenbedingungen, Motivationen und Aktionen einzelner Akteurinnen und Gruppen mit Schwerpunkt ab den 1970/80er Jahren wider. Der Band zeigt auf, wie eng gesellschaftliche und wissenschaftliche Diskurse miteinander verflochten sind.
Landfrauenküche (Bd. 7)
Ob Schwaben, Oberfranken oder Niederbayern – aus allen sieben Regionen Bayerns kommen die Landfrauen zusammen, um füreinander zu kochen und sich auszutauschen. Im siebten Buch zur erfolgreichen TV-Serie »Landfrauenküche« im Bayrischen Fernsehen sind aller guten Dinge drei: Fantasievolle und doch bodenständige Gerichte, stimmungsvolle Lebensgeschichten und tolle Bilder aus dem Alltagsleben der bayrischen Landfrauen bilden das Erfolgsrezept für einen authentischen, kulinarischen Lesegenuss. Hier werden Küchenklassiker wie Tafelspitz neu interpretiert, die Tagliatelle hausgemacht und die frisch ausgebackenen Apfelküchle noch lauwarm serviert. Dieses Buch versammelt alle bebilderten Rezepte der 13. sowie der kommenden 14. Staffel und weitere Lieblingsgerichte von jeder der 14 Landfrauen – natürlich auch viele vegetarisch. Der besondere Charme dieser Ausgabe liegt zudem darin, dass einer der drei Gänge nach einem Familienrezept der Landfrauen gekocht wird. Hier ist traditionell erprobter Genuss garantiert!
