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Drug Discovery for Schizophrenia
Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book covers new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of induced pluripotent stem cells. The combination of these important areas benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.
Animal Models in Biological Psychiatry
In this book, experts from academia introduce the reader to some of the recent new developments in the field of experimental modelling of various brain disorders. Covering data from neuroethology to neurogenetics and psychopharmacology, this book collects a number of outstanding state-of-the-art papers on the topic, collected by the Russian Society for BioPsychiatry. They will give us a brief, but sound, resume of the reasons why it is so important to study biological markers of brain pathology, and in so doing, discuss the various challenges and available opportunities.
Behavioral Models in Stress Research
Stress is an adaptive response that has developed throughout evolution, and is associated with multiple changes in the biochemistry, histology and physiology of an organism. As stress may induce or contribute to multiple neuropsychiatric disorders, the rigorous investigation of the neural substrates of stress has become a critical endeavour of contemporary biomedical science. This book explores the physiological responses that researchers have attempted to assess in stress-evoked behavioural changes, using both human and animal "experimental" models in clinical and non-clinical research. Though all aspects of the field have their challenges, animal experimental research of stress is a particularly difficult but meaningful task. This book provides succinct and relevant summaries of progress in the area of assessing stress response and the conditions contributing to it.
Current Antipsychotics
Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into th...
Brain, Behavior and Epigenetics
Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similaritie...
Scientific and Technical Revolution: Yesterday, Today and Tomorrow
This book presents a system view of the digital scientific and technological revolution, including its genesis and prerequisites, current trends, as well as current and potential issues and future prospects. It gathers selected research papers presented at the 12th International Scientific and Practical Conference, organized by the Institute of Scientific Communications. The conference “Artificial Intelligence: Anthropogenic Nature vs. Social Origin” took place on December 5–7, 2019 in Krasnoyarsk, Russia. The book is intended for academic researchers and independent experts studying the social and human aspects of the Fourth Industrial Revolution and the associated transition to the d...
What's Wrong With My Mouse?
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutan...
Stress Resilience
Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience. This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it. Approaches resilience as a process rather than as a static trait Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance Presents thorough coverage of both the genetic and environmental factors that contribute to resilience
The Psychosis-Risk Syndrome
Using the authors' over thirteen years of experience at the psychosis-risk clinic at Yale University School of Medicine, The Psychosis-Risk Syndrome presents a concise handbook that details the diagnostic tools and building blocks that comprise the Structural Interview for Psychosis-Risk Syndromes, or SIPS. Clear and to the point, this volume provides an in-depth description of this new clinical high-risk population, along with instructions on how to use the SIPS to evaluate persons for psychosis-risk.The handbook's main section takes the reader step-by-step through the SIPS evaluation, tracking how patients and families find their way to the clinic, the initial interview, the evaluation process, and the summary session consisting of findings and future options. The core diagnostic symptoms of the SIPS and psychosis-risk states are illustrated with dozens of symptom and case examples drawn from real but disguised patients from the Yale clinic. With an emphasis on clinical usefulness, the handbook finishes with "practice cases" for the reader to test his or her new skills at evaluating clinical populations for psychosis-risk.
Topical Issues of Rational use of Natural Resources 2019
Topical Issues of Rational Use of Natural Resources 2019 contains the contributions presented at the XV International Forum-Contest of Students and Young Researchers under the auspices of UNESCO (St. Petersburg Mining University, Russia, 13-17 May 2019). The Forum-Contest is a great opportunity for young researchers to present their work to the academics involved or interested the area of extraction and processing of natural resources. The topics of the book include: Volume 1 • Geotechnologies of resource extraction: current challenges and prospects • Solid minerals mining technologies. Industrial and labour safety • Underground space development technologies. Rock mechanics and contro...
