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Drug Discovery for Schizophrenia
Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book covers new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of induced pluripotent stem cells. The combination of these important areas benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.
Behavioral Models in Stress Research
Stress is an adaptive response that has developed throughout evolution, and is associated with multiple changes in the biochemistry, histology and physiology of an organism. As stress may induce or contribute to multiple neuropsychiatric disorders, the rigorous investigation of the neural substrates of stress has become a critical endeavour of contemporary biomedical science. This book explores the physiological responses that researchers have attempted to assess in stress-evoked behavioural changes, using both human and animal "experimental" models in clinical and non-clinical research. Though all aspects of the field have their challenges, animal experimental research of stress is a particularly difficult but meaningful task. This book provides succinct and relevant summaries of progress in the area of assessing stress response and the conditions contributing to it.
Animal Models in Biological Psychiatry
In this book, experts from academia introduce the reader to some of the recent new developments in the field of experimental modelling of various brain disorders. Covering data from neuroethology to neurogenetics and psychopharmacology, this book collects a number of outstanding state-of-the-art papers on the topic, collected by the Russian Society for BioPsychiatry. They will give us a brief, but sound, resume of the reasons why it is so important to study biological markers of brain pathology, and in so doing, discuss the various challenges and available opportunities.
Brain, Behavior and Epigenetics
Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similaritie...
What's Wrong With My Mouse?
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutan...
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Meth...
Cognitive Enhancement in Schizophrenia and Related Disorders
A practical guide on how to assess and treat schizophrenia and related disorders using cognitive rehabilitation.
Stress Resilience
Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience. This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it.
Drug Discovery for Schizophrenia
Following progress in schizophrenia since 2015, this new volume covers the advancing knowledge of scientists and clinicians in drug discovery. The book enhances our understanding of pathological neural communication between the peripheral nervous system (PNS) and central nervous system (CNS) in patients with schizophrenia. Although 75% of neural information passes through the PNS, interactions between the PNS and CNS in schizophrenia remain understudied. Consequently, the current view of schizophrenia requires improvement to facilitate diagnostics and drug development. In this context, this second volume presents current evidence that views schizophrenia as a mild abnormal maldevelopment of ...
The Permian Timescale
This volume brings together state-of-the-art reviews of the non-biostratigraphic and biostratigraphic data that are used to define and correlate Permian time intervals. It includes analyses of Permian radio-isotopic ages, magnetostratigraphy, isotope-based stratigraphy and timescale-relevant biostratigraphy. It is the first book devoted to this subject and represents the cutting edge of Permian time-scale research.
