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Proceedings of the Fourth International Conference held in Hong Kong, October 4-7, 1995
Ca2+ signaling in neurons is characterized by highly restricted and dynamic gradients called Ca2+ waves, spikes, transients and puffs depending upon their corresponding spatial and temporal features. Based on this strict segmentation the Ca2+ ion provides a versatile basis for complex signaling in neuronal subcompartments with a spatial resolution of micro- and nanodomains. The multitude of Ca2+-regulated processes requires specialized downstream processing machinery, translating the Ca2+ signal into alterations of cellular processes. The broad range of different Ca2+-triggered phenomena in neurons, ranging from neurotransmission to gene expression, is reflected by the existence of a multitu...
The University of Cambridge has produced more Nobel Prize-winning economists than the whole of France. This impressive book collects together largely unpublished correspondence from some of the twentieth century's key figures including Keynes, Robinson, Hayek and Sraffa.
Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have bee...
The central portion of Oregon's Willamette Valley is home to present-day Mt. Angel. The history of this charismatic town bursts with a sense of community. The town has always maintained a strong set of values that supports its residents in educational, financial, and leisure activities. In the early 1900s, even though it was a small, rural town, the residents of Mt. Angel were able to finance the construction of churches, schools, and businesses. They were also able to lobby for a railroad line to provide transportation for people and crops. The lively community has earned a reputation throughout the state for its festivals and German heritage. Oktoberfest, a yearly celebration since 1966, includes traditional dances, music, food, beer, and activities for all ages. The festival attracts over 300,000 visitors each year and is considered by many to be the largest festival in Oregon.
Calcium signalling is an astonishing example how a simple caption can trigger and regulate an enormous variety of cellular and physiological responses. Ca2+-signalling routes very often involve Ca2+-binding proteins that sense changes in intracellular [Ca2+] and trigger cellular responses by regulating specific targets. One fascinating group among these Ca2+-sensors are the neuronal calcium sensor (NCS) proteins, named for their localisation in neuronal tissue (although there are reports of their expression in non-neuronal tissues as well). While recent excellent reviews have covered key aspects of this protein group, the field expanded in recent years making it more and more difficult to represent every facet of this ongoing research endeavour. This book is intended to represent properties of NCS proteins.