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Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3
Proceedings of the Fourth International Conference held in Hong Kong, October 4-7, 1995
Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase Modulation of Neuronal and Cardiovascular Signal Transduction
The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
Neuronal Calcium Sensor Proteins
Calcium signalling is an astonishing example how a simple caption can trigger and regulate an enormous variety of cellular and physiological responses. Ca2+-signalling routes very often involve Ca2+-binding proteins that sense changes in intracellular [Ca2+] and trigger cellular responses by regulating specific targets. One fascinating group among these Ca2+-sensors are the neuronal calcium sensor (NCS) proteins, named for their localisation in neuronal tissue (although there are reports of their expression in non-neuronal tissues as well). While recent excellent reviews have covered key aspects of this protein group, the field expanded in recent years making it more and more difficult to represent every facet of this ongoing research endeavour. This book is intended to represent properties of NCS proteins.
Gaudi's Puzzle
A professor of architecture and history at a university outside of Chicago, Josef Pachin suddenly finds his marriage and career unraveling. Still reeling from the death of his parents in a fiery car crash, Josef is further shocked to discover that they were survivors from Auschwitz. Josef retreats to the solitude of a Polish diner to ponder his life and meets the elderly Ada Bolensky. Ada knew his parents in the concentration camps, and she may hold the key to learning about his past. But what secret did they take to their grave about Gaudi's Puzzle? More importantly, why is the secret sect known as the Royal Order of Gaudi trying to kill him? Traveling from Poland to Spain in search of the answers, Josef narrowly escapes with his life. He races against time to solve the riddle before the portal to the puzzle is sealed for eternity.
The Neuronal Functions of EF-hand Ca(2+)-binding Proteins 2nd Edition
Ca2+ signaling in neurons is characterized by highly restricted and dynamic gradients called Ca2+ waves, spikes, transients and puffs depending upon their corresponding spatial and temporal features. Based on this strict segmentation the Ca2+ ion provides a versatile basis for complex signaling in neuronal subcompartments with a spatial resolution of micro- and nanodomains. The multitude of Ca2+-regulated processes requires specialized downstream processing machinery, translating the Ca2+ signal into alterations of cellular processes. The broad range of different Ca2+-triggered phenomena in neurons, ranging from neurotransmission to gene expression, is reflected by the existence of a multitu...
Mt. Angel
The central portion of Oregon's Willamette Valley is home to present-day Mt. Angel. The history of this charismatic town bursts with a sense of community. The town has always maintained a strong set of values that supports its residents in educational, financial, and leisure activities. In the early 1900s, even though it was a small, rural town, the residents of Mt. Angel were able to finance the construction of churches, schools, and businesses. They were also able to lobby for a railroad line to provide transportation for people and crops. The lively community has earned a reputation throughout the state for its festivals and German heritage. Oktoberfest, a yearly celebration since 1966, includes traditional dances, music, food, beer, and activities for all ages. The festival attracts over 300,000 visitors each year and is considered by many to be the largest festival in Oregon.
Botulinum and Tetanus Neurotoxins
Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have bee...
