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This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition t...
Detailing commonly used methods and procedures, this reference discusses the reactions and derivative forms of carbohydrates. Preparative Carbohydrate Chemistry covers the formation, cleavage, and reactions of derivatives and illustrates bond-forming reactions of SN2 types, free radicals, chain extensions, and branching. The contents include: sugar derivatives; selected reactions in carbohydrate chemistry; chemical synthesis of oligosaccharides and O-and N -glycosyl compounds; enzymatic synthesis of sialic acid, KDO, and related deoxyulosonic acids, and of oligosaccharides; synthesis of -glycosyl compounds; carbocycles from carbohydrates; and total synthesis of sugars from non-sugars. This authoritative reference offers relevant chapters on reactions and derivative forms of carbohydrates, including commonly used methods as well as new experimental procedures. It also contains insightful chapter commentaries and succinct topic histories.
The final installment of Oldenbourg's bestselling and brilliant historical trilogy describes the fate and misfortune of the noble Seigneur of Montgeil and his family, victims of the cruel "Fourth Crusades" at the beginning of the 13th century.
Kniha přináší přes čtyřicet příspěvků mezinárodního kolektivu autorů a jejím záměrem je především shromáždit a popsat střípky předchozích, zapomenutých způsobů života. Lidský život a evoluce překlenuje různé historické epochy i místa, osud člověka se však zdá neúprosný, protože svědkové, vzpomínky i hmatatelné důkazy lidské existence se nevyhnutelně vytrácejí. Kniha současně odráží výsledky široké, mezinárodní spolupráce Jiřího A. Svobody, významného vědce, s autory příspěvků, včetně těch, kteří se jeho dílem inspirují.
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In 1208 Pope Innocent III called for a Crusade against a country of fellow- Christians. The new enemy was Raymond VI, Count of Toulouse, one of the greatest princes in Western Christendom, premier baron of all the territories in southern France. So began the Albigensian Crusade, which was to culminate in 1244 with the massacre of Cathars at the mountain fortress of Montsegur.